189497
Autophagy Inducer, STF-62247
A cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL-deficient, but not VHL-expressing, renal carcinoma cells both in vitro and in mice in vivo.
别名:
Autophagy Inducer, STF-62247, N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine
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About This Item
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质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
beige
溶解性
DMSO: 50 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
[s]1c(nc(c1)c3ccncc3)Nc2cc(ccc2)C
InChI
1S/C15H13N3S/c1-11-3-2-4-13(9-11)17-15-18-14(10-19-15)12-5-7-16-8-6-12/h2-10H,1H3,(H,17,18)
InChI key
KATNUHQNJGNLPW-UHFFFAOYSA-N
一般描述
A cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL- (von Hippel-Lindau) deficient, but not VHL-expressing, renal carcinoma cells both in vitro (IC50 = 0.625 and 16 µM in RCC4 and RCC4/VHL killing, respectively) and in mice in vivo (>90% 786-O tumor growth suppression; 8 mg/kg via daily i.p.). Although STF-62247 induces autophagy regardless of cellular VHL-expression level, STF-62247 treatment is shown to result in more enhanced/acidified autolysomes formation in VHL-deficient cells, implicating an important role of VHL in maintaining normal vesicular trafficking between ER, TNG, and lysosomes.
包装
Packaged under inert gas
警告
Toxicity: Toxic (F)
其他说明
Turcotte, S., et al. 2008. Cancer Cell14, 90.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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