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Merck
CN

189490

3-MA

≥95% (HPLC), powder, autophagy inhibitor, Calbiochem®

别名:

自噬抑制剂，3-MA, 3-甲基腺嘌呤

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关于此项目

经验公式（希尔记法）:
C6H7N5
化学文摘社编号:
5142-23-4
分子量:
149.15
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00010531

主要文件

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产品名称

自噬抑制剂，3-MA, Autophagy Inhibitor, 3-MA, CAS 5142-23-4, is a cell-permeable autophagic sequestration blocker. Acts as an inhibitor of III PI3-Kinase.

SMILES string

N1(C2=NC=NC2=C(N=C1)N)C

InChI

1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H3

InChI key

FSASIHFSFGAIJM-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white to faint yellow

solubility

DMSO: 10 mg/mL
water: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

相关类别

Disclaimer

毒性：标准处理（A）

General description

一种广泛使用的细胞渗透性自噬隔离阻滞剂，可有效保护小脑颗粒细胞免于血清/钾缺乏后的凋亡。尽管也被成为III类PI3K抑制剂（在无细胞酶法测定中IC50 = 4.5 mM），3-MA展现出了与其他两种PI3K抑制剂显著不同的药理属性，即LY 294002（货号440202和440204）以及Wortmannin（货号681675）

Other Notes

Canu, N., et al. 2005.J. Neurochem.92, 1228.
Hirosako, K., et al. 2004.Biochem.Biophys.Res. Commun.316, 845.
Beugnet, A., et al. 2003.生物化学。J.372, 555.
Eskelinen, E.L., et al. 2002.Traffic3, 878.
Petiot, A., et al. 2000.J. Biol. Chem.275, 992.
Seglen, P.O. and Gordon, P.B., 1982.Proc.Natl.Acad.Sci. USA79, 1889.

Packaging

用惰性气体包装

Preparation Note

在重悬后分装并冻存于冰箱（-20°C。储备溶液在-20°C下可稳定保存至多3个月。
在需要高工作浓度（例如10 mM）的应用中，使用预制的储备液可能会导致将比所需溶剂（例如DMSO）高的溶剂引入实验体系。在这种情况下，建议在将要使用时通过称量固体化合物并直接重新配制成用于实验系统的溶液（缓冲液、培养基等）。可能需要涡旋以实现在水中的完全溶解。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Wei Huang et al.
Frontiers in neuroscience, 15, 745815-745815 (2021-12-07)
Parkinson's disease is a neurodegenerative disorder with an inflammatory response as the core pathogenic mechanism. Previous human genetics findings support the view that the loss of TREM2 function will aggravate neurodegeneration, and TREM2 is one of the most highly expressed
Jinghui Zhai et al.
Journal of biochemical and molecular toxicology, 35(11), e22896-e22896 (2021-08-24)
The NOD-like receptor family pyrin domain-containing (NLRP3) inflammasomes is centrally implicated in cisplatin (CP)-induced kidney injury. Autophagy is critical for inhibiting production of NLRP3 protein that effectively reduces the inflammatory response. Ginsenoside Rg3 (SY), an active component extracted from ginseng
Cong Chen et al.
Cell death & disease, 13(2), 150-150 (2022-02-16)
Ferroptosis, which is characterized by intracellular iron accumulation and lipid peroxidation, is a newly described form of regulated cell death that may play a key role in tumour suppression. In the present study, we investigated the expression profiles and biological
Julie Devin et al.
Cancer research, 82(6), 998-1012 (2022-01-27)
Diffuse large B-cell lymphoma (DLBCL) is the most common hematological malignancy. Although more than half of patients with DLBCL achieve long-term remission, the majority of remaining patients succumb to the disease. As abnormal iron homeostasis is implicated in carcinogenesis and
Nienke Visser et al.
International journal of molecular sciences, 22(5) (2021-03-04)
Elevated activation of the autophagy pathway is currently thought to be one of the survival mechanisms allowing therapy-resistant cancer cells to escape elimination, including for cytarabine (AraC)-resistant acute myeloid leukemia (AML) patients. Consequently, the use of autophagy inhibitors such as
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Expression of genetically-encoded fluorescently-tagged proteins has widely been employed for real-time visualization of cellular behavior and trafficking. Prepackaged, ready-to-use, high-titer lentiviral particles (which we have termed “lentiviral biosensors”) encoding GFP- or RFP-tagged proteins are a convenient, robust solution for fluorescent imaging of transduced cells. Compared to other nonviral transfection methods, lentiviral transduction, in many cases, offers higher transfection efficiency and more homogeneous protein expression, particularly for traditionally hard-to-transfect primary cell types. Lentiviral biosensors are ideal for use with fixed and live cell fluorescent microscopy, and are non-disruptive towards cellular function. GFP- or RFP-protein localization matches well with antibody-based immunostaining and demonstrates altered patterns of expression upon treatment with modulators of cell function and phenotype. Lentiviral biosensors provide a broadly effective, convenient method for visualization of cell behavior under a variety of physiological and pathological treatment conditions, in both endpoint and real-time imaging modalities. In this study, we focus on lentiviral biosensors containing GFP-LC3 and RFP-LC3 for the study of autophagosome formation.

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