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Merck
CN
所有图片(1)

文件

182015

Sigma-Aldrich

Cyclo(Arg-Gly-Asp-D-Phe-Val)

Potent inhibitor of cell adhesion.

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别名:
Cyclo(Arg-Gly-Asp-D-Phe-Val), RGDFV Peptide, Cyclic
经验公式（希尔记法）:
C26H38N8O7
CAS号:
137813-35-5
分子量:
574.63
UNSPSC代码:
12352202
NACRES:
NA.77

质量水平

100

检测方案

≥95% (HPLC)

形式

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)

颜色

white

溶解性

1 N acetic acid: 5 mg/mL

运输

ambient

储存温度

−20°C

一般描述

Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion. Inhibits the redistribution of c-Src into focal adhesions, thereby leading to impaired MAP Kinase activation.
Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion.

生化/生理作用

Cell permeable: no
Primary Target
inhibits tumor cell adhesion to laminin and vitronectin substrates
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Standard Handling (A)

其他说明

Shono, T., et al. 2001. Exp. Cell Res.268, 169.
Matsuno, H., et al. 1994. Circulation 90, 2203.
Noiri, E., et al. 1994. Kidney Int. 46, 1050.
Gurrath, M., et al. 1992. Eur. J. Biochem. 210, 911.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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