178501
Palmostatin B
≥95% (HPLC), solid, APT1 inhibitor, Calbiochem®
别名:
APT1抑制剂，palmostatin B, APT1抑制剂
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关于此项目
经验公式（希尔记法）:
C23H36O4
分子量:
376.53
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
产品名称
APT1抑制剂，palmostatin B, The APT1 Inhibitor, palmostatin B controls the biological activity of APT1.
Quality Level
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 100 mg/mL
shipped in
wet ice
storage temp.
−20°C
General description
一种细胞可渗透的β-内酯酰基蛋白硫酯酶1（APT1）抑制剂（在酶促测定中IC50 = 0.67 µM），在体外和体内均能特异性阻断MDCK细胞中的Ras去棕榈酰化而不影响Ras酰化。它诱导NRas显著重新分布到内膜（1 µM），而没有明显的细胞毒性，并且显示出在同一细胞系中引起棕榈酰化Ras蛋白精确稳态定位的丧失。在50 µM时，该抑制剂在致癌的HRasG12V转化的成纤维细胞中显示出部分表型逆转。此外，它证明了APT1对磷脂酶A1、A2、Cβ和D的选择性。其′抑制作用与siRNA下调APT1的抑制作用一致。也可以作为50 mM的DMSO溶液（目录号508738）提供。
Packaging
用惰性气体包装
Other Notes
Dekker, F. and Hedberg, C. 2011.Bioorg.Med. Chem. Lett.19, 1376.
Dekker, F., et al. 2010.Nat. Chem. Biol.6, 449.
Dekker, F., et al. 2010.Nat. Chem. Biol.6, 449.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
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存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 178501-5MG | 04055977204834 |