推荐产品
产品名称
夹竹桃麻素, A cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase.
质量水平
方案
≥98% (GC)
表单
powder
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white to off-white
溶解性
DMSO: 10 mg/mL
ethanol: 20 mg/mL
运输
ambient
储存温度
−20°C
SMILES字符串
O(C)c1c(ccc(c1)C(=O)C)O
InChI
1S/C9H10O3/c1-6(10)7-3-4-8(11)9(5-7)12-2/h3-5,11H,1-2H3
InChI key
DFYRUELUNQRZTB-UHFFFAOYSA-N
一般描述
一种细胞可透过性抗炎酚类化合物，可作为 NADPH 氧化酶的有效和选择性抑制剂。研究表明，可阻断鼠巨噬细胞中过亚硝酸盐的形成。据报道，可通过激活 AP-1 增加谷胱甘肽的合成。还有有报道表明，可防止巨噬细胞（10 mM）吞噬髓磷脂。
一种细胞可透过性抗炎酚，可作为 NADPH 氧化酶的有效和选择性抑制剂。还可阻断鼠巨噬细胞中过亚硝酸盐的形成。据报道，可通过激活 AP-1 增加谷胱甘肽的合成。研究表明，可防止巨噬细胞（10 mM）吞噬髓磷脂。
生化/生理作用
主靶
NADPH 氧化酶
NADPH 氧化酶
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有
包装
用惰性气体包装
警告
毒性：刺激性（B）
重悬
重悬后，等分并冷冻（-20°C）。储备溶液在-20°C下可稳定保存至多6个月。
其他说明
Abid, M.R., et al. 2000.FEBS Lett.486, 252.
Muijsers, R.B., et al. 2000.Br. J. Pharmacol.130, 932.
Lapperre, T.S., et al. 1999.FEBS Lett.443, 235.
Supinski, G., et al. 1999, J. Appl. Physiol.87, 776.
van der Goes, A., et al. 1998.J. Neuroimmunol.92, 67.
Hart, B.A., and Simmons, J.M.1992.Biotechnol.Ther.3, 3.
Muijsers, R.B., et al. 2000.Br. J. Pharmacol.130, 932.
Lapperre, T.S., et al. 1999.FEBS Lett.443, 235.
Supinski, G., et al. 1999, J. Appl. Physiol.87, 776.
van der Goes, A., et al. 1998.J. Neuroimmunol.92, 67.
Hart, B.A., and Simmons, J.M.1992.Biotechnol.Ther.3, 3.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 2
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