product name
阿非迪霉素, Aphidicolin, CAS 38966-21-1, is a cell-permeable antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase.
质量水平
检测方案
≥98% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
white
溶解性
DMSO: 50 mg/mL
ethanol: soluble
methanol: soluble
运输
ambient
储存温度
2-8°C
InChI
1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
InChI key
NOFOAYPPHIUXJR-APNQCZIXSA-N
一般描述
细胞可透过性四环二萜抗生素。细胞同步化试剂将细胞周期阻滞在S期早期。真核细胞和某些动物源病毒DNA聚合酶α和δ的特异性抑制剂。可增强阿糖核苷诱导白血病细胞凋亡的作用。还可诱导HeLa S3细胞凋亡，但会抑制长春新碱诱导人p53阴性前列腺癌细胞系PC-3凋亡的作用。
细胞可透过性四环二萜抗生素，可作为细胞同步化试剂。将细胞周期阻滞在S期早期。真核细胞和某些病毒DNA聚合酶α和δ的特异性抑制剂。可增强阿糖核苷诱导白血病细胞凋亡的作用。还可诱导HeLa S3细胞凋亡，但会抑制长春新碱诱导人p53阴性前列腺癌细胞系PC-3凋亡的作用。也可以30 mM的DMSO溶液（货号504744）中的25 mM溶液。
生化/生理作用
主要靶标
DNA聚合酶α，DNA聚合酶 δ
DNA聚合酶α，DNA聚合酶 δ
产品不与ATP竞争。
可逆：否
细胞渗透性：是
警告
毒性：标准处理（A）
重悬
溶解后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存2个月。
其他说明
Borner, M.M., et al. 1995.Cancer Res.55, 2122.
Poluha, W., et al. 1995.Oncogene 10, 185.
Urbani, L., et al. 1995.Exp.Cell Res. 219, 159.
Schimke, R.T., et al. 1994.Philos.Trans.R. Soc.London.B. Biol. Sci.345, 311.
Kuwakado, K., et al. 1993.Biochem.Pharmacol.46, 1909.
Hubermann, J.A.1981.Cell23, 647.
Poluha, W., et al. 1995.Oncogene 10, 185.
Urbani, L., et al. 1995.Exp.Cell Res. 219, 159.
Schimke, R.T., et al. 1994.Philos.Trans.R. Soc.London.B. Biol. Sci.345, 311.
Kuwakado, K., et al. 1993.Biochem.Pharmacol.46, 1909.
Hubermann, J.A.1981.Cell23, 647.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Sobhan Haghparast et al.
Scientific reports, 13(1), 19800-19800 (2023-11-14)
Fusion of multiple chemically identical complexes, so-called particles, in localization microscopy, can improve the signal-to-noise ratio and overcome under-labeling. To this end, structural homogeneity of the data must be assumed. Biological heterogeneity, however, could be present in the data originating
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Nucleic acids research, 50(5), 2681-2699 (2022-02-22)
Cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) is activated in cells with defective DNA damage repair and signaling (DDR) factors, but a direct role for DDR factors in regulating cGAS activation in response to micronuclear DNA is still poorly understood. Here
Michaël Lehoux et al.
Methods in molecular biology (Clifton, N.J.), 1249, 67-80 (2014-10-29)
Replication of the human papillomavirus (HPV) double-stranded DNA genome in the nucleus of infected cells relies on the viral proteins E1 and E2 in conjunction with the host DNA replication machinery. This process is tightly linked to the replication of
Weitao Wang et al.
Molecular cell, 81(14), 2975-2988 (2021-06-23)
The heterogeneous nature of eukaryotic replication kinetics and the low efficiency of individual initiation sites make mapping the location and timing of replication initiation in human cells difficult. To address this challenge, we have developed optical replication mapping (ORM), a
P Logan Schuck et al.
The Journal of biological chemistry, 297(3), 101026-101026 (2021-08-03)
Sister chromatid cohesion (SCC), the pairing of sister chromatids after DNA replication until mitosis, is established by loading of the cohesin complex on newly replicated chromatids. Cohesin must then be maintained until mitosis to prevent segregation defects and aneuploidy. However
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