176901
Anthrax Lethal Factor Protease Inhibitor, In-2-LF
The Anthrax Lethal Factor Protease Inhibitor, In-2-LF controls the biological activity of Anthrax Lethal Factor Protease. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
别名:
Anthrax Lethal Factor Protease Inhibitor, In-2-LF, Anthrax LF Protease Inhibitor, Bacillus anthracis LF Protease Inhibitor, In-2-LF
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About This Item
经验公式（希尔记法）:
C81H150N42O17
分子量:
1984.33
UNSPSC代码:
12352200
NACRES:
NA.77
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质量水平
方案
≥97% (HPLC)
表单
lyophilized solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
颜色
white
溶解性
water: 1 mg/mL
5% acetic acid: 5 mg/mL
DMSO: 5 mg/mL
运输
wet ice
储存温度
−20°C
一般描述
A cell-permeable N-acetylated, C-hydroxamate derivative of a 14-mer peptide designed from the MEK-2 template that acts as a competitive inhibitor of Anthrax lethal factor (LF) metalloprotease (Ki = 1 nM). Also inhibits MEK-3 cleavage. Protects against Anthrax toxin induced cytotoxicity in RAW264.7 and J772.A1 cells.
A cell-permeable derivative of a 14-mer peptide that is based on the MEK-2 template and acts as a competitive inhibitor of Anthrax lethal factor metalloprotease (Ki = 1 nM). Also inhibits MEK-3 cleavage. Exhibits protective effects against Anthrax toxin-induced cytotoxicity in RAW264.7 and J772.A1 cells. Reported to competitively inhibit furin (Ki = 49 nM.
生化/生理作用
Cell permeable: yes
Primary Target
anthrax LF metalloprotease
anthrax LF metalloprotease
Product does not compete with ATP.
Reversible: no
Target Ki: 1 nM against Anthrax lethal factor (LF) metalloprotease
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
序列
Ac-Gly-Tyr-βAla-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Val-Leu-Arg-NHOH
外形
Supplied as a trifluoroacetate salt.
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Peinado, J.R., et al. 2004. Biochem. Biophys. Res. Commun.321, 601.
Tonello, F., et. al. 2002. Nature418, 386.
Tonello, F., et. al. 2002. Nature418, 386.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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