175580
Angiogenesis Inhibitor
The Angiogenesis Inhibitor, also referenced under CAS 186611-44-9, controls the biological activity of Angiogenesis. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Angiogenesis Inhibitor, ( Z,E)-3-(Imidazol-4-ylmethylene)indolin-2-one, (Z,E)-3-(Imidazol-4-ylmethylene)indolin-2-one
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About This Item
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质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
yellow
溶解性
DMSO: 5 mg/mL
运输
ambient
储存温度
2-8°C
一般描述
A cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 µM in an in vitro rat aortic ring model ) with a potency that is comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 µM). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 µM).
A cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 µM in an in vitro rat aortic ring model). The potency has been reported to be comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 µM). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 µM).
生化/生理作用
Cell permeable: yes
Primary Target
hEGF-R tyrosine kinase activity
hEGF-R tyrosine kinase activity
Product competes with ATP.
Reversible: no
Target IC50: 54% inhibition at 10 µM against hEGF-R tyrosine kinase activity
包装
Packaged under inert gas
警告
Toxicity: Carcinogenic / Teratogenic (D)
其他说明
Braud, E., et al. 2003. J. Enzyme Inhib. Med. Chem.18, 243.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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