172104
Anaphase-Promoting Complex Inhibitor, TAME
The Anaphase-Promoting Complex Inhibitor, TAME, also referenced under CAS 1784-03-8, controls the biological activity of Anaphase-Promoting Complex. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
别名:
Anaphase-Promoting Complex Inhibitor, TAME, TAME hydrochloride, APC/C Inhibitor I, APC/C-Cdc20 Interaction Inhibitor I, Cyclosome Inhibitor I
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所有图片(2)
About This Item
经验公式（希尔记法）:
C14H22N4O4S · xHCl
CAS号:
分子量:
342.41 (free base basis)
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.54
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质量水平
方案
≥98% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 50 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
[S](=O)(=O)(NC(CCC[N+H]=C(N)N)C(=O)OC)c1ccc(cc1)C.[Cl-]
InChI
1S/C14H22N4O4S.ClH/c1-10-5-7-11(8-6-10)23(20,21)18-12(13(19)22-2)4-3-9-17-14(15)16;/h5-8,12,18H,3-4,9H2,1-2H3,(H4,15,16,17);1H
InChI key
JIQFFACVQXXHMY-UHFFFAOYSA-N
一般描述
TAME is a potent ubiquitin ligase inhibitor that specifically blocks Anaphase-Promoting Complex (APC) activation by directly binding to APC and disrupts the IR-tail-dependent interactions between APC and its activator proteins Cdc20 or Cdh1. It stabilizes APC substrates and is shown to inhibit cyclin proteolysis in mitotic Xenopus egg extract with an IC50 = 12 µM.
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Sackton, K.L., et al. 2014. Nature. In press.
Zeng, X., et al. 2010. Cancer Cell18, 382.
Zeng, X., et al. 2010. Cancer Cell18, 382.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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