164606
Aminopeptidase N/CD13 Inhibitor
The Aminopeptidase N/CD13 Inhibitor controls the biological activity of Aminopeptidase N/CD13. This small molecule/inhibitor is primarily used for Neuroscience applications.
别名:
Aminopeptidase N/CD13 Inhibitor, 4-tert-butylphenyl hydrogen 1-aminopropylphosphonate
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About This Item
经验公式（希尔记法）:
C13H22NO3P
分子量:
271.29
UNSPSC代码:
12352200
NACRES:
NA.77
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质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
white
溶解性
0.1 M NaOH: 1 mg/mL
DMSO: 1 mg/mL (Only partially soluble)
water: 1 mg/mL (only partially soluble)
运输
wet ice
储存温度
−20°C
一般描述
An alpha-aminoaralkylphosphonic acid ester that acts as an aminopeptidase N/CD13 inhibitor (IC50=1.1 µM). Cell growth is dose dependently inhibited by as much as ~36% and ~60% in PANC-1 and HT-1080 cells, respectively when 300 µM of compound 4d is co-treated with 30 µg/ml of TNF. When treated with compound 4d alone, cell growth is dose-dependently inhibited by as much as 26% and 36%, in the same cell lines, respectively.
An alpha-aminoaralkylphosphonic acid ester that acts as an aminopeptidase N/CD13 inhibitor (IC50=1.1 µM). Cell growth is dose dependently inhibited by as much as ~36% and ~60% in PANC-1 and HT-1080 cells, respectively when 300 µM of compound 4d is co-treated with 30 µg/ml of TNF. When treated with compound 4d alone, cell growth is dose-dependently inhibited by as much as 26% and 36%, in the same cell lines, respectively.
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Grzywa, R., et al. 2010. Bioorg. Med. Chem.8, 2930.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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