biological source
Porcine kidney
form
suspension (crystalline)
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
physiological buffer: soluble
water: soluble
foreign activity
Oxidases ≤3%
shipped in
ambient
storage temp.
2-8°C
Quality Level
Application
猪肾氨基肽酶M已用于：
- 测试并鉴定促咽侧体神经肽相关肽（ATRP）中的含d-残基峰
- 研究其对酶活性的氧化失活并筛查MIRA成分
- 异缩酮（IsoLG）蛋白的蛋白水解
Biochem/physiol Actions
氨基肽酶M（APM）与大脑中某些神经肽（如脑啡肽和血管紧缩素）作用的终止有关。它也代谢某些血管活性肽。它可作为某些病毒（如冠状病毒229E）的受体。APM是一种非特异性肽酶，可快速裂解I-残基肽。
Disclaimer
毒性：有害（C）
General description
氨基肽酶M（APM）大量存在于肾、小肠、胎盘、肝脏的刷状缘膜（brush border membrane）。它是一种II型整合膜蛋白，也称为胞外酶。
Other Notes
Wachsmuth, E.E., et al. 1966.Biochemistry5, 169.
一个单位定义为在37°C，pH 7.2下，每分钟水解1 µ mol Leu-pNA的酶量。
Packaging
请参考特定浓度批号的标签。
Physical form
在3.2 M (NH₄)₂SO₄、10 mM MgCl₂、10 mM Tris-HCl（pH 7.5）中的晶体混悬液。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
James W Checco et al.
The Journal of biological chemistry, 293(43), 16862-16873 (2018-09-09)
l- to d-residue isomerization is a post-translational modification (PTM) present in neuropeptides, peptide hormones, and peptide toxins from several animals. In most cases, the d-residue is critical for the biological function of the resulting d-amino acid-containing peptide (DAACP). Here, we
Oral Delivery of Peptide Formulations and Their Cellular Evaluation
Patil S, et al.
International Journal of Peptide Research and Therapeutics, 27(4), 2831-2844 (2021)
Handbook of Proteolytic Enzymes (2012)
Valery N Yermalitsky et al.
Analytical biochemistry, 566, 89-101 (2018-11-21)
Isolevuglandins (IsoLGs) are a family of highly reactive 4-ketoaldehydes formed by lipid peroxidation that modify the lysyl residues of cellular proteins. Modification of proteins by IsoLGs have been shown to contribute to disease processes such as the development of hypertension.
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