16-319
Anti-Rac1 Antibody, clone 23A8, Magnetic bead Conjugate
purified antibody, clone 23A8, from mouse
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别名:
Cell migration-inducing gene 5 protein, Ras-like protein TC25, migration-inducing gene 5, migration-inducing protein 5, ras-related C3 botulinum toxin substrate 1, ras-related C3 botulinum toxin substrate 1 (rho family,small GTP binding protein Rac1), ra
UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41
推荐产品
生物来源
mouse
质量水平
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
23A8, monoclonal
种属反应性
human, rat, mouse
技术
immunoprecipitation (IP): suitable
western blot: suitable
同位素/亚型
IgG2b
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... RAC1(5879)
一般描述
Rac1 is a member of a RhoGTPase subfamily (Rac1-Rac4) that transduces extracellular signals from G-coupled protein receptors (GPCR), integrins and growth factor receptors to effector molecules that modulate multiple signaling pathways. While Rac1 supports the activation of MAPkinase pathways and gene activation, it’s most important functions include the regulation of cytoskeletal structures. Together with Rho (regulator of stress fibers) and Cdc42 (regulator of filopodia), Rac modulates the formation of focal adhesion (FA) complexes; membrane ruffles and lamellipodia that contribute to important cell functions related to cell attachment and movement.
特异性
Other species have not been tested.
Recognizes human Rac1.
应用
Anti-Rac1 Antibody, clone 23A8, Magnetic bead Conjugate detects level of Rac1 & has been published & validated for use in WB & IP.
目标描述
21 kDa
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt. DO NOT FREEZE! Wash the magnetic beads with an appropriate buffer prior to use to remove sodium azide.
WGK
WGK 2
Mian Zhou et al.
Cellular & molecular immunology, 20(1), 80-93 (2022-12-06)
In sepsis, macrophage bacterial phagocytosis is impaired, but the mechanism is not well elucidated. Extracellular cold-inducible RNA-binding protein (eCIRP) is a damage-associated molecular pattern that causes inflammation. However, whether eCIRP regulates macrophage bacterial phagocytosis is unknown. Here, we reported that
Armin Bayati et al.
Cell reports, 40(3), 111102-111102 (2022-07-21)
The nervous system spread of alpha-synuclein fibrils is thought to cause Parkinson's disease (PD) and other synucleinopathies; however, the mechanisms underlying internalization and cellular spread are enigmatic. Here, we use confocal and superresolution microscopy, subcellular fractionation, and electron microscopy (EM)
Zihang Chen et al.
The Journal of physiology, 598(12), 2415-2430 (2020-04-03)
Spinal cord dorsal horn srGAP3 (slit-robo GTPase activating protein 3) increases in the initiation phase of neuropathic pain and decreases in the maintenance phase. However, Rac1 activity, which can be reduced by srGAP3, decreases in the initiation phase and increases
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