16-233
Anti-FAK Antibody, clone 4.47, Alexa Fluor™ 488 conjugate
clone 4.47, Upstate®, from mouse
别名:
Anti-FADK, Anti-FADK 1, Anti-FAK, Anti-FAK1, Anti-FRNK, Anti-PPP1R71, Anti-p125FAK, Anti-pp125FAK
产品名称
Anti-FAK Antibody, clone 4.47, Alexa Fluor™ 488 conjugate, clone 4.47, Upstate®, from mouse
biological source
mouse
conjugate
ALEXA FLUOR™ 488
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
4.47, monoclonal
species reactivity
human, rat, mouse
manufacturer/tradename
Upstate®
technique(s)
flow cytometry: suitable
immunocytochemistry: suitable
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PTK2(5747)
Analysis Note
Routinely evaluated by immunostaining of 3T3 cells.
Application
Detect FAK using this Anti-FAK Antibody, clone 4.47, Alexa Fluor 488 conjugate validated for use in FC, WB & IC.
Research Category
Signaling
Signaling
Research Sub Category
Cytoskeletal Signaling
Cytoskeletal Signaling
Biochem/physiol Actions
p125FAK, does not cross react with Pyk-2
Disclaimer
Alexa Fluor™ is a registered trademark of Molecular Probes, Inc.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
125kDa
Immunogen
GST fusion protein corresponding to residues 1-423 of human FAK (focal adhesion kinase)
Physical form
Protein G Purified
Preparation Note
1 year at 4°C from date of shipment
Legal Information
ALEXA FLUOR is a trademark of Life Technologies
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Steven K Hanks et al.
Frontiers in bioscience : a journal and virtual library, 8, d982-d996 (2003-04-18)
Focal adhesion kinase (FAK) was first described in 1992 as a novel nonreceptor protein-tyrosine kinase localized prominently within focal adhesions, suggesting a signaling role in regulating cell behavior resulting from integrin interaction with the extracellular matrix. Subsequent studies over the
Nam Cong-Nhat Huynh et al.
PloS one, 11(7), e0159843-e0159843 (2016-07-22)
Rinsing the mouth with sodium chloride (NaCl) solution is believed to promote healthy gum and improve oral ulcer healing. Scientific evidence to support this assumption is, however, lacking. This study aims to investigate the effect and clarify underlying mechanisms of
Focal adhesion kinase: in command and control of cell motility.
Mitra, Satyajit K, et al.
Nature Reviews in Molecular and Cell Biology, 6, 56-68 (2005)
David D Schlaepfer et al.
Current opinion in genetics & development, 14(1), 92-101 (2004-04-28)
The ability of intracellular signaling networks to orchestrate a complex biological response such as cell motility requires that individual signaling proteins must act as integrators, responding to multiple extracellular inputs and regulating multiple signaling pathway outputs. In this review, we
Control of motile and invasive cell phenotypes by focal adhesion kinase.
Schlaepfer, David D, et al.
Biochimica et Biophysica Acta, 1692, 77-102 (2004)
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