推荐产品
生物来源
mouse
质量水平
偶联物
ALEXA FLUOR™ 488
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
4F11, monoclonal
种属反应性
bovine, human, mouse, rat, hamster, avian
制造商/商品名称
Upstate®
技术
flow cytometry: suitable
immunocytochemistry: suitable
immunofluorescence: suitable
western blot: suitable
同位素/亚型
IgG1
NCBI登记号
UniProt登记号
运输
wet ice
基因信息
human ... CTTN(2017)
特异性
Recognizes Cortactin in rodent and human cells
免疫原
Mixture of affinity-purified tyrosine phosphoproteins from chick embryo fibroblasts expressing activated pp60src
应用
Detect Cortactin (p80/85) using this Anti-Cortactin (p80/85) Antibody, clone 4F11, Alexa Fluor 488 validated for use in FC, IF, WB & IC.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Cytoskeleton
Cytoskeleton
质量
Routinely evaluated by immunoblot.
目标描述
Mr 80kDa and in avian cells, Mr 80kDa and 85kDa
外形
Protein G Purified
储存及稳定性
1 year at 4°C from date of shipment
分析说明
Control
Negative Control: Catalog # 16-240, Normal Mouse IgG, ALEXA FLUOR™ 488-conjugate.
Negative Control: Catalog # 16-240, Normal Mouse IgG, ALEXA FLUOR™ 488-conjugate.
法律信息
ALEXA FLUOR is a trademark of Life Technologies
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Alexa Fluor is a registered trademark of Molecular Probes, Inc.
Alexa Fluor is a registered trademark of Molecular Probes, Inc.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Hax-1 is required for Rac1-Cortactin interaction and ovarian carcinoma cell migration.
Gomathinayagam, R; Muralidharan, J; Ha, JH; Varadarajalu, L; Dhanasekaran, DN
Genes & Cancer null
C Dehio et al.
The EMBO journal, 14(11), 2471-2482 (1995-06-01)
Shigella flexneri causes bacillary dysentery in humans by invading epithelial cells of the colon. Cell invasion occurs via bacterium-directed phagocytosis, a process requiring polymerization of actin at the site of bacterial entry. We show that invasion of HeLa cells by
C Guinebault et al.
The Journal of cell biology, 129(3), 831-842 (1995-05-01)
Thrombin-induced accumulation of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) but not of PtdIns(3,4,5,)P3 is strongly correlated with the relocation to the cytoskeleton of 29% of the p85 alpha regulatory subunit of phosphoinositide 3-kinase (PtdIns 3-kinase) and is accompanied by a significant increase in
Cortactin phosphorylation as a switch for actin cytoskeletal network and cell dynamics control.
Lua, Bee Leng and Low, Boon Chuan
Febs Letters, 579, 577-585 (2005)
M A McNiven et al.
The Journal of cell biology, 151(1), 187-198 (2000-10-06)
The dynamin family of large GTPases has been implicated in the formation of nascent vesicles in both the endocytic and secretory pathways. It is believed that dynamin interacts with a variety of cellular proteins to constrict membranes. The actin cytoskeleton
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