推荐产品
生物来源
mouse
质量水平
抗体产品类型
primary antibodies
克隆
4.47, monoclonal
种属反应性
human
制造商/商品名称
Upstate®
技术
immunoprecipitation (IP): suitable
NCBI登记号
UniProt登记号
运输
wet ice
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此商品 | 71008BC | 71007BC | 71007ATMBC |
|---|---|---|---|
| technique(s) PCR: suitable | technique(s) PCR: suitable | technique(s) PCR: suitable | technique(s) PCR: suitable |
| application(s) food and beverages | application(s) food and beverages | application(s) food and beverages | application(s) food and beverages |
| storage temp. room temp | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| manufacturer/tradename Assurance GDS® | manufacturer/tradename BioControl Systems 71008-100 | manufacturer/tradename BioControl Systems 71007-100 | manufacturer/tradename BioControl Systems 71007-576ATM |
| Quality Level EQ2 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
一般描述
Anti-FAK monoclonal antibody (05-537), covalently coupled to Protein G agarose by dimethyl-pimelimidate
应用
Research Category
Signaling
Signaling
Research Sub Category
Cytoskeletal Signaling
Cytoskeletal Signaling
Suitable for immunoprecipitation and affinity purification.
This Anti-FAK Antibody, clone 4.47, agarose conjugate is validated for use in IP for the detection of FAK.
特点和优势
Format: Gel Immobilized
质量
routinely evaluated by immunoprecipitating FAK from a mouse 3T3/A31 RIPA cell lysate, as confirmed by subsequent immunoblot analysis using anti-FAK (05-537)
外形
PBS containing 0.05% sodium azide
储存及稳定性
2 years at 4°C
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Eugene Ciccimaro et al.
Molecular pharmacology, 75(3), 658-666 (2008-12-23)
A recently developed stable isotope dilution liquid chromatography-multiple reaction/mass spectrometry method to quantify focal adhesion kinase (FAK) activation loop phosphorylation was used to study endogenous Src kinase activity. This revealed that bis-phosphorylated pTyr(576)/Tyr(577)-FAK was a biomarker of Src activity and
Attila Aszodi et al.
Genes & development, 17(19), 2465-2479 (2003-10-03)
Beta1 integrins are highly expressed on chondrocytes, where they mediate adhesion to cartilage matrix proteins. To assess the functions of beta1 integrin during skeletogenesis, we inactivated the beta1 integrin gene in chondrocytes. We show here that these mutant mice develop
Eugene Ciccimaro et al.
Analytical chemistry, 81(9), 3304-3313 (2009-04-10)
A vital point of convergence for many signaling pathways at cellular focal adhesions is the interaction of two nonreceptor tyrosine kinases, focal adhesion kinase (FAK) and Src. The binding of Src to FAK leads to the phosphorylation of Y(576) and
Gabriela D'Amico et al.
Development (Cambridge, England), 149(13) (2022-06-21)
Precise vascular patterning is crucial for normal growth and development. The ERG transcription factor drives Delta-like ligand 4 (DLL4)/Notch signalling and is thought to act as a pivotal regulator of endothelial cell (EC) dynamics and developmental angiogenesis. However, molecular regulation
Elena Kurenova et al.
Cell cycle (Georgetown, Tex.), 13(16), 2542-2553 (2014-12-09)
Melanoma has the highest mortality rate of all skin cancers and a major cause of treatment failure is drug resistance. Tumors heterogeneity requires novel therapeutic strategies and new drugs targeting multiple pathways. One of the new approaches is targeting the
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