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生物来源
human
质量水平
重组
expressed in baculovirus infected Sf21 cells
分子量
Mw 77 kDa
制造商/商品名称
Upstate®
技术
activity assay: suitable (kinase)
NCBI登记号
UniProt登记号
基因信息
human ... PIP5K1C(23396)
一般描述
N-terminal 6His-tagged, recombinant human PIP5K1γ, full length.
Product Source: Expressed by baculovirus in Sf21 insect cells
应用
Active, N-terminal 6His-tagged, recombinant human PIP5K1γ, full length. For use in Kinase Assays.
Research Category
Signaling
Signaling
Research Sub Category
Oncology
Inflammation & Autoimmune Mechanisms
Diabetes
Alzheimer′s Disease
Neurodegenerative Diseases
Oncology
Inflammation & Autoimmune Mechanisms
Diabetes
Alzheimer′s Disease
Neurodegenerative Diseases
生化/生理作用
Protein Target: PIP5K1γ
Target Sub-Family: PIPK
包装
Also available in 250μg size as catalog # 14-845M - Call for pricing and availability.
质量
Routinely evaluated in the PIProfiler.
外形
Immobilized metal affinity chromatography (IMAC)
10µg of enzyme in 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 0.2mM PMSF, 1mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution.
储存及稳定性
6 months at -70°C
其他说明
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Development of a High-Throughput Screening Assay to Identify Inhibitors of the Lipid Kinase PIP5K1C.
Brittany D Wright et al.
Journal of biomolecular screening, 20(5), 655-662 (2014-12-24)
Phosphatidylinositol 4-phosphate 5-kinases (PIP5Ks) regulate a variety of cellular processes, including signaling through G protein-coupled receptors (GPCRs), endocytosis, exocytosis, and cell migration. These lipid kinases synthesize phosphatidylinositol 4,5-bisphosphate (PIP2) from phosphatidylinositol 4-phosphate [PI(4)P]. Because small-molecule inhibitors of these lipid kinases
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