mTOR（1362端）蛋白，活性，10 µg

Research area: Cell Signaling

Protein Target: mTOR (FRAP1)

Target Sub-Family: Lipid/Atypical

N-terminal FLAG-tagged, recombinant, human mTOR, amino acids 1362-end

The mechanistic target of rapamycin (mTOR) protein is a serine/threonine protein kinase belonging to PI3K-related kinase (PIKK) family, expressed throughout the body.

The active mTOR (1362-end) protein, 10 µg, has been used in the mTOR substrate phosphorylation assay to validate the biochemical and pharmacological profile of a novel mTOR-KI for targeting mTOR signaling pathways in vitro and in vivo.

Mechanistic target of rapamycin (mTOR) plays a pivotal role in regulating various essential cellular processes, ranging from protein synthesis to autophagy. Moreover, it influences metabolism, cellular survival, gene transcription, and cytoskeletal components. It gets activated in response to growth factors, nutrients, mitogens, and hormones.Downregulation of mTOR signaling is associated with the advancement of cancer and diabetes, and aging process.

也有100 μg规格，请查询价格和供货情况。

比活：其中一个单位的mTOR活性定义为在30°C下每分钟将1 nmole磷酸盐掺入2 mg/ml mTOR底物中，最终ATP浓度为100 µM。

在100 µL 10mM HEPES、50mM NaCl、50 mMβ-甘油磷酸盐、0.25 mM原钒酸钠、10 mM NaF、300 µg/mL FLAGTM肽、20%v/v甘油中加入16 µg酶

储存在-70°C。 为了最大程度地回收产品，在取下盖子之前，将原始样品瓶进行离心。

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