14-730-M
c-Kit (V560G) Protein, active, 10 µg
Active, N-terminal GST tagged recombinant human c-Kit, amino acids 544 -end, containing the V560G mutation, found in patients with gastrointestinal stromal tumours. For use in Kinase Assays.
别名:
Mast/stem cell growth factor receptor, SCFR, CD117
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所有图片(1)
About This Item
UNSPSC代码:
12352202
eCl@ss:
32160405
NACRES:
NA.32
推荐产品
生物来源
human
质量水平
100
300
分子量
Mw 76.6 kDa
制造商/商品名称
Upstate®
技术
activity assay: suitable (kinase)
NCBI登记号
UniProt登记号
基因信息
human ... KIT(3815)
一般描述
N-terminal GST tagged recombinant human c-Kit, amino acids 544 - end, containing the V560G mutation. The V560G mutation has been found in patients with gastrointestinal stromal tumours and has been linked to poor prognosis. This mutation confers increased susceptibility to Gleevec.
Product Source: Human c-Kit (V560G) expressed in Sf21 insect cells.
质量
Routinely evaluated by phosphorylation of 250μM GGMEDIYFEFMGGKKK.
外形
Presented as a frozen solution in 50mM Tris/HCl pH 7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij 35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, and 0.1% 2-mercaptoethanol.
其他说明
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Warning
危险声明
危险分类
Skin Sens. 1
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Juxtamembrane mutant V560GKit is more sensitive to Imatinib (STI571) compared with wild-type c-kit whereas the kinase domain mutant D816VKit is resistant.
Frost, Michelle J, et al.
Molecular Cancer Therapeutics, 1, 1115-1124 (2002)
An in vivo tumor model exploiting metabolic response as a biomarker for targeted drug development.
Cullinane C, Dorow DS, Kansara M, Conus N, Binns D, Hicks RJ, Ashman LK, McArthur GA, Thomas DM.
Cancer Research, 65, 9633-9636 (2005)
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