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生物来源
human
质量水平
重组
expressed in baculovirus infected Sf21 cells
分子量
Mw 63.8 kDa
制造商/商品名称
Upstate®
技术
activity assay: suitable (kinase)
NCBI登记号
UniProt登记号
一般描述
Research area: CELL SIGNALING
Product Source: expressed by baculovirus in Sf21 cells
The anaplastic lymphoma kinase (ALK) is a member of the insulin receptor superfamily of receptor tyrosine kinases. The ALK gene is located on human chromosome 2p23 and shares a high similarity with the leukocyte tyrosine kinase (Ltk). ALK is composed of three domains: an extracellular domain responsible for ligand binding, a transmembrane domain that spans the cell membrane, and a cytoplasmic domain housing the tyrosine kinase activity. The cytoplasmic tyrosine kinase domain of ALK plays a significant role in disease pathologies associated with the gene. Within the structure, there are two short conserved β-strands (β7-β8) housing majority of the catalytic residues. Full-length ALK is specifically expressed in the developing central and peripheral nervous systems during embryogenesis and is associated with the balance of cell proliferation and differentiation.
Product Source: expressed by baculovirus in Sf21 cells
The anaplastic lymphoma kinase (ALK) is a member of the insulin receptor superfamily of receptor tyrosine kinases. The ALK gene is located on human chromosome 2p23 and shares a high similarity with the leukocyte tyrosine kinase (Ltk). ALK is composed of three domains: an extracellular domain responsible for ligand binding, a transmembrane domain that spans the cell membrane, and a cytoplasmic domain housing the tyrosine kinase activity. The cytoplasmic tyrosine kinase domain of ALK plays a significant role in disease pathologies associated with the gene. Within the structure, there are two short conserved β-strands (β7-β8) housing majority of the catalytic residues. Full-length ALK is specifically expressed in the developing central and peripheral nervous systems during embryogenesis and is associated with the balance of cell proliferation and differentiation.
应用
Research Category
Inflammation & Immunology
Inflammation & Immunology
生化/生理作用
Protein Target: ALK
Target Sub-Family: TK Anaplastic lymphoma kinase (ALK) plays a crucial role in the development of neurons. Binding of ligand to its extracellular domain triggers the activation of the tyrosine kinase that in turn activates the mitogen-activated protein kinase (MAPK) pathway. ALK fusion proteins induce the activation of diverse pathways including Phospholipase C gamma (PLC-γ) and Ras/Extracellular Signal-Regulated Kinase 1/2 (Ras/ERK1/2), which contribute to cell proliferation, while the Janus Kinase/signal transducer and activator of transcription (JAK/STAT) pathway and Phosphoinositide 3-kinase/Protein Kinase B (PI3K/Akt) pathways facilitate cell survival. Notably, ALK has been found to be overexpressed in various human tumors and cell lines such as lymphomas, neuroblastoma, and non-small-cell lung cancer.
Target Sub-Family: TK Anaplastic lymphoma kinase (ALK) plays a crucial role in the development of neurons. Binding of ligand to its extracellular domain triggers the activation of the tyrosine kinase that in turn activates the mitogen-activated protein kinase (MAPK) pathway. ALK fusion proteins induce the activation of diverse pathways including Phospholipase C gamma (PLC-γ) and Ras/Extracellular Signal-Regulated Kinase 1/2 (Ras/ERK1/2), which contribute to cell proliferation, while the Janus Kinase/signal transducer and activator of transcription (JAK/STAT) pathway and Phosphoinositide 3-kinase/Protein Kinase B (PI3K/Akt) pathways facilitate cell survival. Notably, ALK has been found to be overexpressed in various human tumors and cell lines such as lymphomas, neuroblastoma, and non-small-cell lung cancer.
质量
routinely evaluated by phosphorylation of IGF-1Rtide
外形
Ni2+/NTA-agarose
储存及稳定性
6 months at -70°C from date of shipment
其他说明
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Mechanism for the activation of the anaplastic lymphoma kinase receptor
Nature, 600(7887), 153-157 (2021)
ALK a novel lymphoma-associated tumor antigen for vaccination strategies.
Leukemia & Lymphoma, 44, 1675-1681 (2003)
Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition
Pharmacological Research, 68(1), 68-94 (2013)
Anaplastic lymphoma kinase proteins in growth control and cancer.
Journal of Cellular Physiology, 199, 330-358 (2004)
Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology
Nature Reviews. Cancer, 13(10), 685-700 (2013)
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