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Merck
CN
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主要文件

14-548-M

Sigma-Aldrich

MSK1 Protein, active, 10 µg

Active, N-terminal His6-tagged recombinant human MSK1 residues 2-end, for use in Kinase Assays.

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About This Item

UNSPSC代码:
12352202
eCl@ss:
32160405
NACRES:
NA.32

生物来源

human

质量水平

100

重组

expressed in baculovirus infected Sf21 cells

产品线

Upstate®

比活

(For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)

分子量

Mw 94 kDa

纯化方式

(Ni2+/NTA-agarose)

种属反应性

human

制造商/商品名称

Upstate®

技术

activity assay: suitable (kinase)

登记号

 (FUNCTION: SwissProt: O75582 # Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of ′Ser-1′ of histone H2A. Phosphorylates ′Ser-10′ of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate ′Ser-28′ of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14). )
NM_004755.2

NCBI登记号

NM_004755.2
NM_182398.1

UniProt登记号

O75582

相关疾病

metabolic disorders; cardiovascular diseases

基因信息

human ... RPS6KA5(9252)

一般描述

N-terminal His6-tagged recombinant human MSK1 residues 2-end

应用

Research Category
Metabolism
Research Sub Category
Cardiovascular Disease

Metabolic Disorders

生化/生理作用

Protein Target: MSK1
Target Sub-Family: AGC

包装

Also available in 10 μg size and in bulk
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-548M when ordering the 250 µg size.

质量

routinely evaluated by phosphorylation of Crosstide

目标描述

MSK1

外形

Ni2+/NTA-agarose

储存及稳定性

6 months at -20°C

其他说明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H317

危险分类

Skin Sens. 1

储存分类代码

10 - Combustible liquids

WGK

WGK 1

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Judit M Pérez Ortiz et al.
Neurobiology of disease, 116, 93-105 (2018-05-15)
Spinocerebellar ataxia type 1 (SCA1) is a polyglutamine (polyQ) repeat neurodegenerative disease in which a primary site of pathogenesis are cerebellar Purkinje cells. In addition to polyQ expansion of ataxin-1 protein (ATXN1), phosphorylation of ATXN1 at the serine 776 residue

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