MSK1 Protein, active, 10 µg

产品名称

MSK1 Protein, active, 10 µg, Active, N-terminal His6-tagged recombinant human MSK1 residues 2-end, for use in Kinase Assays.

biological source

human

recombinant

expressed in baculovirus infected Sf21 cells

product line

Upstate^®

specific activity

(For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)

mol wt

M_w 94 kDa

purified by

(Ni²⁺/NTA-agarose)

species reactivity

human

manufacturer/tradename

Upstate^®

technique(s)

activity assay: suitable (kinase)

accession no.

 (FUNCTION: SwissProt: O75582 # Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of ′Ser-1′ of histone H2A. Phosphorylates ′Ser-10′ of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate ′Ser-28′ of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14). )
NM_004755.2

NCBI accession no.

NM_004755.2
NM_182398.1

UniProt accession no.

O75582

relevant disease(s)

metabolic disorders; cardiovascular diseases

Quality Level

100

Gene Information

human ... RPS6KA5(9252)