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产品名称
Abl (T315I) Protein, active, 10 µg, Active, N-terminal His6-tagged recombinant human Abl, residues 27-end containing the T315I mutation. For use in Kinase Assays.
生物来源
human
重组
expressed in baculovirus infected Sf21 cells
分子量
Mw 121 kDa
制造商/商品名称
Upstate®
技术
activity assay: suitable (kinase)
NCBI登记号
UniProt登记号
一般描述
N-terminal His6-tagged recombinant human Abl, residues 27-end containing the T315I mutation
Contains the gatekeeper mutation T315I in the ATP-binding domain. This mutation decreases the sensitivity to Gleevec by more than 200-fold as compared to the wild type sequence.
Contains the gatekeeper mutation T315I in the ATP-binding domain. This mutation decreases the sensitivity to Gleevec by more than 200-fold as compared to the wild type sequence.
Product Source: Expressed by baculovirus in Sf21 insect cells
应用
Research Category
Metabolism
Inflammation & Immunology
Metabolism
Inflammation & Immunology
Research Sub Category
Obesity
Metabolic Disorders
Osteoporosis
Arthritis
Obesity
Metabolic Disorders
Osteoporosis
Arthritis
生化/生理作用
Protein Target: Abl
Target Sub-Family: TK
包装
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-522M when ordering the 250 µg size.
质量
routinely evaluated by phosphorylation of Abltide
外形
Ni2+/NTA-agarose
储存及稳定性
6 months at -70°C
其他说明
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance
Gumireddy, K., et al
Proceedings of the National Academy of Sciences of the USA, 102, 1992-1997 (2005)
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