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生物来源
human
质量水平
重组
expressed in E. coli
分子量
Mw 61 kDa
制造商/商品名称
Upstate®
技术
activity assay: suitable (kinase)
NCBI登记号
UniProt登记号
基因信息
human ... CSNK1D(1453)
一般描述
Research area: Cell signaling
Research Category: Metabolism Research
Subcategory: Obesity
Protein Target: CK1γδ
Target Sub-Family: CK1
Casein Kinase 1δ (CK1δ ) is a serine/threonine kinase that belong to the family of casein kinase 1. The protein structure consists of anti-parallel β-sheet strands at N-terminal lobe (N-lobe) and α-helices and loop structures at the larger C-terminal lobe (C-lobe).
Research Category: Metabolism Research
Subcategory: Obesity
Protein Target: CK1γδ
Target Sub-Family: CK1
Casein Kinase 1δ (CK1δ ) is a serine/threonine kinase that belong to the family of casein kinase 1. The protein structure consists of anti-parallel β-sheet strands at N-terminal lobe (N-lobe) and α-helices and loop structures at the larger C-terminal lobe (C-lobe).
应用
Research Category
Metabolism
Metabolism
Research Sub Category
Obesity
Metabolic Disorders
Obesity
Metabolic Disorders
生化/生理作用
Casein Kinase 1δ (CK1δ) is implicated in multiple cellular processes, including membrane trafficking, cytokinesis, circadian rhythm, and tumorigenesis. It interacts with critical molecules within cancer-related signaling pathways, such as Wnt/β-catenin, PI3K/AKT, and Hedgehog. Therefore, mutations or overexpression of the CK1δ coding gene can potentially contribute to the onset and progression of cancer.
包装
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-520M when ordering the 250 µg size.
质量
routinely evaluated by phosphorylation of KRRRALS(p)VASLPGL
外形
Glutathione-agarose
储存及稳定性
6 months at -20°C
其他说明
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
警示用语：
Warning
危险声明
危险分类
Skin Sens. 1
储存分类代码
10 - Combustible liquids
WGK
WGK 2
Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D)
Xu P, et al.
Gene: X, 2019-2019 (2019)
Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D)
Xu P, et al.
A Manual for Genetic Engineering: Advanced Bacterial Genetics, 715 (2019)
Francesca Vena et al.
Molecular cancer therapeutics, 19(8), 1623-1635 (2020-05-21)
Although gemcitabine is the cornerstone of care for pancreatic ductal adenocarcinoma (PDA), patients lack durable responses and relapse is inevitable. While the underlying mechanisms leading to gemcitabine resistance are likely to be multifactorial, there is a strong association between activating
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