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Merck
CN
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主要文件

14-516-M

Sigma-Aldrich

Cdk5/p25 Protein, active, 10 µg

Active complex of N-terminal His6-tagged, recombinant, full-length human Cdk5 & N-terminal GST-tagged, recombinant, full-length human p25, for use in Kinase Assays.

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About This Item

UNSPSC代码:
12352202
eCl@ss:
32160405
NACRES:
NA.32

生物来源

human

质量水平

100

重组

expressed in baculovirus infected Sf21 cells

分子量

Mw 34.4 kDa (cdk5)
Mw 49.4 kDa (p25)

制造商/商品名称

Upstate®

技术

activity assay: suitable (kinase)

NCBI登记号

NM_004935.2

UniProt登记号

Q00535

一般描述

Complex of N-terminal His6-tagged, recombinant, full-length human cdk5 and Nterminal GST-tagged, recombinant, full-length human p25
Product Source: Co-expressed by baculovirus in Sf21 insect cells

应用

Research Category
Metabolism
Research Sub Category
Obesity

Metabolic Disorders

生化/生理作用

Protein Target: CDK5/p25
Target Sub-Family: CMGC

包装

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-516M when ordering the 250 µg size.

质量

routinely evaluated by phosphorylation of Histone H1

外形

Ni2+/NTA-agarose

储存及稳定性

1 year at -70°C

其他说明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Qiaoyun Chu et al.
Cancer medicine, 10(11), 3689-3699 (2021-05-08)
The marked overexpression of cyclin-dependent kinase 5 (CDK5) or Notch1 receptor, which plays critical roles in pancreatic ductal adenocarcinoma (PDAC) development, has been detected in numerous PDAC cell lines and tissues. Although, a previous study has demonstrated that CDK5 inhibition

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