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生物来源
human
质量水平
重组
expressed in Sf21 cells
分子量
Mw 48.7 kDa
制造商/商品名称
Upstate®
技术
activity assay: suitable (kinase)
NCBI登记号
UniProt登记号
基因信息
human ... RPS6KB1(6198)
一般描述
N-terminal His6-tagged, recombinant amino acids 1-421 of human p70 S6 kinase
Product Source: Expressed in Sf21 cells
生化/生理作用
Protein Target: p70S6K
Target Sub-Family: AGC
包装
Also available in 250μg size as catalog # 14-486M.
质量
Routinely evaluated by phosphorylation of S6 Kinase/Rsk-2 Substrate Peptide 2
外形
Ni2+/NTA-agarose
储存及稳定性
6 months at -70°C
其他说明
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Jason A Lehman et al.
The Journal of biological chemistry, 278(30), 28130-28138 (2003-05-13)
We report here for the first time the detection of the ribosomal p70S6 kinase (p70S6K) in a hematopoietic cell, the neutrophil, and the stimulation of its enzymatic activity by granulocyte macrophage colony-stimulating factor (GM-CSF). GM-CSF modified the Vmax of the
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