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生物来源
human
质量水平
重组
expressed in baculovirus infected Sf21 cells
产品线
Upstate®
比活
(For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)
保质期
1 yr
分子量
Mw 78 kDa
纯化方式
(Ni2+/NTA-agarose)
种属反应性
human
制造商/商品名称
Upstate®
技术
activity assay: suitable (kinase)
登记号
(FUNCTION: SwissProt: P17252 # PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. )
NM_002737.2
NCBI登记号
UniProt登记号
储存温度
−70°C
基因信息
human ... PRKCA(5578)
一般描述
Research area: Apoptosis
Protein Target: PKCα
Target Sub-Family: AGC
Protein Target: PKCα
Target Sub-Family: AGC
Recombinant, full-length human PKCα, containing N-terminal His6 tag
应用
Active, recombinant, full-length human PKCα, containing N-terminal His6 tag. For use in Kinase Assays.
生化/生理作用
Protein kinase C-α (PKCα), an isoform of protein kinase C, exhibits an anti-apoptotic and pro-proliferative function. It is commonly upregulated in tumor cells, and its depletion has been associated with apoptosis induction. The anti-apoptotic effects of PKCα are mediated through mechanisms such as phosphorylation of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2) and activation of the pro-survival protein kinase AKT. The inhibition of PKCα leads to the activation of a PKCδ-dependent apoptotic pathway in salivary epithelial cells. PKCα regulates cell cycle progression in glioma cells by increasing the expression of p21 cyclin-dependent kinase inhibitor 1 (p21 (Waf1/Cip1)), a protein involved in cell cycle regulation.
包装
Also available in 10 μg size and in bulk
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-484M when ordering the 250 µg size.
质量
routinely evaluated by phosphorylation of Histone H1.
目标描述
PKCα
外形
Ni2+/NTA-agarose
储存及稳定性
1 year at -70°C
其他说明
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
警示用语:
Warning
危险声明
危险分类
Skin Sens. 1
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°C)
Not applicable
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