推荐产品
生物来源
human
质量水平
重组
expressed in E. coli
expressed in BL21 DE3 cells
产品线
Upstate®
比活
(For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)
分子量
Mw 40.7 kDa
纯化方式
chromatography
种属反应性
human
制造商/商品名称
Upstate®
技术
activity assay: suitable (kinase)
登记号
(FUNCTION: SwissProt: P17612 # Phosphorylates a large number of substrates in the cytoplasm and the nucleus. )
NM_002730.3
NCBI登记号
UniProt登记号
一般描述
Research area: Cell Signaling
Product Source: Expressed in E.coli BL21 (DE3) pLysS cells Recombinant human full length PKA, catalytic subunit type alpha, untagged Protein kinase A (PKA) is a serine protein kinase and heterotetrameric holoenzyme that targets serine and threonine residues.
Product Source: Expressed in E.coli BL21 (DE3) pLysS cells Recombinant human full length PKA, catalytic subunit type alpha, untagged Protein kinase A (PKA) is a serine protein kinase and heterotetrameric holoenzyme that targets serine and threonine residues.
Recombinant human full length PKA, catalytic subunit type alpha, untagged
生化/生理作用
Protein Target: PKA; Target Sub-Family: AGC. Protein kinases are vital for integrating signaling networks within eukaryotic cells. In Hedgehog-responsive cells, PKA is crucial for regulating proliferation and fate determination by influencing Hedgehog signaling transduction. PKA has numerous targets that are linked to adhesion or migration.
包装
也提供250 µg的规格-订购250 µg的规格时，请致电咨询价格和供货情况，参考目录号14-440M。
Also available in 10 μg size and in bulk
质量
通过体外Kemptide底物的磷酸化进行常规评估
routinely evaluated by phosphorylation of Kemptide substrate in vitro
目标描述
PKA
联系
替代：14-114
外形
磷酸纤维素P11色谱法
储存及稳定性
在-70°C下保存1年
其他说明
比活相关数据，请参阅检验报告以获取该酶的单独批次。
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存分类代码
10 - Combustible liquids
WGK
WGK 1
PKA: a portrait of protein kinase dynamics
Taylor SS, et al.
Biochimica et Biophysica Acta, 1697(1-2), 259-269 (2004)
Protein kinase A
Morrison H
Journal of Separation Science, 173-178 (2021)
Dana Yoo et al.
The Journal of biological chemistry, 278(25), 23066-23075 (2003-04-10)
The Kir1.1 (ROMK) subtypes of inward rectifier K+ channels mediate potassium secretion and regulate sodium chloride reabsorption in the kidney. The density of ROMK channels on the cortical collecting duct apical membrane is exquisitely regulated in concert with physiological demands.
Prokaryotic expression of catalytic subunit of adenosine cyclic monophosphate-dependent protein kinase.
Yonemoto, W M, et al.
Test, 200, 581-596 (1991)
Protein Kinase A Activity and Hedgehog Signaling Pathway
Kotani T
Vitamins and Hormones, 88, 273-291 (2012)
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