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Merck
CN
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主要文件

14-347-M

Sigma-Aldrich

CHK2 Protein, active, 10 µg

Active, recombinant human CHK2, residues 5-543, containing N-terminal GST & C-terminal His-6 tags, for use in Kinase Assays.

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About This Item

UNSPSC代码:
12352202
eCl@ss:
32160405
NACRES:
NA.32

生物来源

human

质量水平

100

重组

expressed in E. coli

产品线

Upstate®

比活

(For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)

分子量

Mw 89.6 kDa

纯化方式

(glutathione-agarose and Ni2+/NTA-agarose)

种属反应性

human

制造商/商品名称

Upstate®

技术

activity assay: suitable (kinase)

登记号

 (FUNCTION: SwissProt: O96017 # Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on ′Ser-216′, preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at ′Thr-18′ and ′Ser-20′. )
NM_001005735.1

NCBI登记号

NM_001005735.1
NM_007194.3
NM_145862.2

UniProt登记号

O96017

基因信息

human ... CHEK2(11200)

一般描述

Recombinant human CHK2, residues 5-543, containing N-terminal GST and Cterminal His6 tags

生化/生理作用

Protein Target: CHK2
Target Sub-Family: CAMK

包装

Also available in 10 μg size and in bulk
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-347M when ordering the 250 µg size.

质量

routinely evaluated by phosphorylation of the CHKtide substrate peptide

目标描述

CHK2

外形

glutathione-agarose and Ni2+/NTA-agarose

储存及稳定性

1 year at -70°C

其他说明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H317

危险分类

Skin Sens. 1

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°C)

Not applicable

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S Matsuoka et al.
Science (New York, N.Y.), 282(5395), 1893-1897 (1998-12-04)
In response to DNA damage and replication blocks, cells prevent cell cycle progression through the control of critical cell cycle regulators. We identified Chk2, the mammalian homolog of the Saccharomyces cerevisiae Rad53 and Schizosaccharomyces pombe Cds1 protein kinases required for

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