生物来源
human
质量水平
分子量
Mw 81.6 kDa
制造商/商品名称
Upstate®
技术
activity assay: suitable (kinase)
NCBI登记号
UniProt登记号
基因信息
human ... CHEK1(1111)
一般描述
N-terminal GST tagged, human full length CHK1
Product Source: expressed in SF21 cells
生化/生理作用
Protein Target: CHK1
Target Sub-Family: CAMK
包装
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-346M when ordering the 250 µg size.
质量
routinely evaluated by phosphorylation of the CHKtide substrate peptide
外形
Glutathione-agarose
储存及稳定性
1 year at -70C
其他说明
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
警示用语：
Warning
危险声明
危险分类
Skin Sens. 1
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
B Furnari et al.
Science (New York, N.Y.), 277(5331), 1495-1497 (1997-09-05)
Arrest of the cell cycle at the G2 checkpoint, induced by DNA damage, requires inhibitory phosphorylation of the kinase Cdc2 in both fission yeast and human cells. The kinase Wee1 and the phosphatase Cdc25, which regulate Cdc2 phosphorylation, were evaluated
Y Sanchez et al.
Science (New York, N.Y.), 277(5331), 1497-1501 (1997-09-05)
In response to DNA damage, mammalian cells prevent cell cycle progression through the control of critical cell cycle regulators. A human gene was identified that encodes the protein Chk1, a homolog of the Schizosaccharomyces pombe Chk1 protein kinase, which is
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