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COA分析证书/COQ

14-246-M

p38γ/SAPK3 Protein, active, 10 µg

Name: p38γ/SAPK3 Protein, active, 10 µg
Brand: MM

Active, recombinant GST fusion protein corresponding to full length human p38γ/SAPK3, for use in Kinase Assays.

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UNSPSC代码:

12352202

eCl@ss:

32160405

NACRES:

NA.32

生物来源

human

质量水平

300

重组

expressed in E. coli

分子量

M_w 69 kDa

制造商/商品名称

Upstate^®

技术

activity assay: suitable (kinase)

一般描述

Product Source: expressed in E. coli

Recombinant GST fusion protein corresponding to full length human p38γ/SAPK3

生化/生理作用

Protein Target: p38γ/SAPK3

Target Sub-Family: CMGC

质量

Routinely evaluated by phosphorylation of MBP in vitro

储存及稳定性

6 months at -70°C

其他说明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

象形图

GHS07

警示用语：

Warning

危险声明

H317

预防措施声明

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

危险分类

Skin Sens. 1

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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The hepatitis B virus HBx protein inhibits caspase 3 activity

Gottlob, K., et al

The Journal of Biological Chemistry, 273, 33347-33353 (1998)

Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38).

A Cuenda et al.

The EMBO journal, 16(2), 295-305 (1997-01-15)

Stress-activated protein kinase-3 (SAPK3), a recently described MAP kinase family member with a wide-spread tissue distribution, was transfected into several mammalian cell lines and shown to be activated in response to cellular stresses, interleukin-1 (IL-1) and tumour necrosis factor (TNF)

Specificity and mechanism of action of some commonly used protein kinase inhibitors.

S P Davies et al.

The Biochemical journal, 351(Pt 1), 95-105 (2000-09-22)

The specificities of 28 commercially available compounds reported to be relatively selective inhibitors of particular serine/threonine-specific protein kinases have been examined against a large panel of protein kinases. The compounds KT 5720, Rottlerin and quercetin were found to inhibit many

Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7.

Y Fleming et al.

The Biochemical journal, 352 Pt 1, 145-154 (2000-11-04)

Stress-activated protein kinase 1 (SAPK1), also called c-Jun N-terminal kinase (JNK), becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses. Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif

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