产品名称
Human recombinant CARM1, Human recombinant CARM1 with an N-terminal FLAG tag expressed in FreeStyle 293-F cells.
recombinant
expressed in FreeStyle™ 293-F cells
mol wt
Mw ~66 kDa
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (histone methyltransferase (HMT))
NCBI accession no.
UniProt accession no.
shipped in
dry ice
Quality Level
Gene Information
human ... CARM1(10498)
Analysis Note
routinely evaluated by methylation of histone H3
Application
Human recombinant CARM1 with an N-terminal FLAG tag expressed in FreeStyle 293-F cells.
Research Category
Nuclear Function
Nuclear Function
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Product Source: Human
Other Notes
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Replaces: 14-575
Varies by lot; see lot-specific datasheet for information on each lot.
Preparation Note
6 months at -80°C.
Legal Information
FreeStyle is a trademark of Invitrogen Corp.
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Melody D Fulton et al.
The Journal of biological chemistry, 297(4), 101123-101123 (2021-09-08)
Histone arginine methylation is a key post-translational modification that mediates epigenetic events that activate or repress gene transcription. Protein arginine methyltransferases (PRMTs) are the driving force for the process of arginine methylation, and the core histone proteins have been shown
Hongwei Li et al.
The Journal of biological chemistry, 277(47), 44623-44630 (2002-09-19)
The RNA-binding protein HuR stabilizes labile mRNAs carrying AU-rich instability elements. This mRNA stabilization can be induced by hypoxia, lipopolysaccharide, and UV light. The mechanism by which these stimuli activate HuR is unclear and might be related to post-translational modification
Seth Frietze et al.
Cancer research, 68(1), 301-306 (2008-01-04)
Estrogen receptor alpha (ER alpha) mediates breast cancer proliferation through transcriptional mechanisms involving the recruitment of specific coregulator complexes to the promoters of cell cycle genes. The coactivator-associated arginine methyltransferase CARM1 is a positive regulator of ER alpha-mediated transcriptional activation.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持