重组
expressed in FreeStyle™ 293-F cells
质量水平
分子量
Mw ~66 kDa
制造商/商品名称
Upstate®
技术
activity assay: suitable (histone methyltransferase (HMT))
NCBI登记号
UniProt登记号
运输
dry ice
基因信息
human ... CARM1(10498)
一般描述
Product Source: Human
应用
Human recombinant CARM1 with an N-terminal FLAG tag expressed in FreeStyle 293-F cells.
Research Category
Nuclear Function
Nuclear Function
质量
routinely evaluated by methylation of histone H3
联系
Replaces: 14-575
储存及稳定性
6 months at -80°C.
其他说明
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Varies by lot; see lot-specific datasheet for information on each lot.
法律信息
FreeStyle is a trademark of Invitrogen Corp.
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Melody D Fulton et al.
The Journal of biological chemistry, 297(4), 101123-101123 (2021-09-08)
Histone arginine methylation is a key post-translational modification that mediates epigenetic events that activate or repress gene transcription. Protein arginine methyltransferases (PRMTs) are the driving force for the process of arginine methylation, and the core histone proteins have been shown
Hongwei Li et al.
The Journal of biological chemistry, 277(47), 44623-44630 (2002-09-19)
The RNA-binding protein HuR stabilizes labile mRNAs carrying AU-rich instability elements. This mRNA stabilization can be induced by hypoxia, lipopolysaccharide, and UV light. The mechanism by which these stimuli activate HuR is unclear and might be related to post-translational modification
Seth Frietze et al.
Cancer research, 68(1), 301-306 (2008-01-04)
Estrogen receptor alpha (ER alpha) mediates breast cancer proliferation through transcriptional mechanisms involving the recruitment of specific coregulator complexes to the promoters of cell cycle genes. The coactivator-associated arginine methyltransferase CARM1 is a positive regulator of ER alpha-mediated transcriptional activation.
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