MBP（髓磷脂碱性蛋白），牛，纯化

髓鞘碱性蛋白（MBP）属于固有无序的蛋白质家族。它在大脑和脊髓神经细胞的绝缘层。它是一种存在于中枢神经系统（CNS）中的丰富蛋白质。

Research area: Cell Signaling
MBP is an alkaline protein with a pI of 11.6, constituting approximately 30% of the total protein content of the myelin in the central nervous system.

经纯化的MBP（牛髓鞘碱性蛋白）已用于免疫印迹，并在酶联免疫吸附测定（ELISA）中用作标准物。

髓鞘碱性蛋白（MBP），也称为髓磷脂执行分子′，有助于中枢神经系统（CNS）髓鞘的形成。多发性硬化症加剧等急性神经障碍以及创伤性脑损伤等患者的脑脊髓液（CSF）中会出现MBP水平升高。此外，在痴呆、脑肿瘤和代谢紊乱等慢性进行性疾病的MBP水平也会升高。 

MBP can interact with various polyanionic proteins such as actin, tubulin, Ca²⁺-calmodulin, and clathrin, as well as negatively charged lipids. Upon binding to these proteins, MBP undergoes structural changes. It is believed to function as a membrane actin-binding protein, potentially enabling its involvement in relaying extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin. External signals received by myelin or cultured oligodendrocytes lead to alterations in the phosphorylation of MBP, indicating its participation in signaling. The peptide MBP4-14 is specific for protein kinase C and is resistant to phosphatase activity. Moreover, MBP is extensively utilized in the "in gel" kinase assay, making it a vital biochemical for studying protein kinase activities.

通过成功地磷酸化活性的 MAP 激酶 2/Erk2 进行了常规评估（货号 14-173）

10mM MOPS，pH 7.0，含 0.05％ 叠氮化钠

在-20°C下可保存2年

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