跳转至内容
Merck
CN

129935

放线菌素D，7-氨基-

7-Aminoactinomycin D, like its parent molecule, actinomycin D, is a DNA intercalator and has antibacterial properties. Exhibits growth-inhibitory activity against certain leukemias and sarcomas.

别名:

放线菌素D，7-氨基-, 7-AAD, 7-氨基-AMD，7-氨基放线菌素C₁, 7-氨基放线菌素

登录 查看组织和合同定价。

选择尺寸

关于此项目

经验公式（希尔记法）:
C62H87N13O16
化学文摘社编号:
7240-37-1
分子量:
1270.43
UNSPSC Code:
12352200
MDL number:
MFCD00077295

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

放线菌素D，7-氨基-, 7-Aminoactinomycin D, like its parent molecule, actinomycin D, is a DNA intercalator and has antibacterial properties. Exhibits growth-inhibitory activity against certain leukemias and sarcomas.

InChI

1S/C62H87N13O16/c1-26(2)42-59(85)74-21-17-19-36(74)57(83)70(13)24-38(76)72(15)48(28(5)6)61(87)89-32(11)44(55(81)66-42)68-53(79)34-23-35(63)30(9)51-46(34)65-47-40(41(64)50(78)31(10)52(47)91-51)54(80)69-45-33(12)90-62(88)49(29(7)8)73(16)39(77)25-71(14)58(84)37-20-18-22-75(37)60(86)43(27(3)4)67-56(45)82/h23,26-29,32-33,36-37,42-45,48-49H,17-22,24-25,63-64H2,1-16H3,(H,66,81)(H,67,82)(H,68,79)(H,69,80)

InChI key

YXHLJMWYDTXDHS-UHFFFAOYSA-N

assay

≥85% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

red-purple

input

sample type intact cells

solubility

DMSO: 20 mg/mL
ethanol: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

主靶
白血病和肉瘤

Disclaimer

毒性：高毒性（H）

General description

7-氨基放线菌素 D 与其母体分子（放线菌素 D）一样，是一种 DNA 嵌入剂，具有抗菌特性。对某些白血病和肉瘤具有抑制生长活性。荧光激发和发射最大值分别为 500 nm 和 672 nm。与 DNA 形成复合物，在 555 nm 处吸收并在 655 nm 处发射。可用于区分早期凋亡细胞（已失去膜完整性）与凋亡和活细胞。已用于 DNA 分析，并作为染色体结构和功能的探针。
7-氨基放线菌素 D 是一种不可渗透膜的荧光 DNA 嵌入剂。像它的母体化合物（放线菌素 D，货号 114666）一样，7-AAD 对某些白血病和肉瘤具有抗菌特性和生长抑制活性。可用于流式细胞术和荧光显微镜检查。用于染色无活力的细胞和鉴定凋亡细胞。与 FITC 和 PE 细胞表面染色兼容。吸收/发射最大值如下：未结合（激发500 nm，发射波长：672 nm）和 DNA 结合（激发555 nm，发射波长：655 nm）。λmax 528 nm ± 2；εmax = 22,700 ± 5,000 M-1 cm-1

Other Notes

Schmid, I., et al. 1994.J. Immunol. Methods170, 145.
Raza, A., et al. 1993.Carcinogenesis14, 103.
Chen, F.M.1992.Biochemistry31, 6223.
Schmid, I., et al. 1992.Cytometry13, 204.
Toba, K., et al. 1992.Cytometry13, 60.
Sengupta, S.K., et al. 1975.J. Med. Chem.18, 1175.
由于该运输中有害物质的性质，您的订单可能需要支付额外的运输费用。某些尺寸的产品可免除其他有害材料的运输费用。请与您当地的销售办事处联系，以获取有关这些费用的更多信息。

Preparation Note

仅在使用前再用水相缓冲液进行稀释。
复溶后，分装，用惰性气体吹扫，然后冻存（-20°C）。储备溶液在-20°C下可稳定保存2个月。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 2 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

法规信息

涉药品监管产品
此项目有

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

David W Doo et al.
Therapeutic advances in medical oncology, 12, 1758835920913798-1758835920913798 (2020-04-22)
The Wnt/β-catenin pathway is linked to tumorigenesis in a variety of tumors and promotes T cell exclusion and resistance to checkpoint inhibitors. We sought to determine whether a small molecule inhibitor of this pathway, WNT974, would impair tumor growth, affect
Xiao-Long Ma et al.
Cell death discovery, 7(1), 309-309 (2021-10-25)
Accumulating evidence has shown that circular RNA (circRNA) dysregulation is involved in various types of cancer, including osteosarcoma (OS). Nevertheless, the role and mechanism of circRNAs in OS progression and chemoresistance remain elusive. We found that a novel doxorubicin-induced circular
Huizhen Yang et al.
Cell biology international, 44(8), 1671-1680 (2020-04-14)
To better treat patients with non-small cell lung cancer (NSCLC), the investigations on novel molecules affecting NSCLC progression are of vital importance. Long noncoding RNAs (lncRNAs) are identified as pivotal regulators that can affect the cellular activities of carcinomas. Long
Whitney N Goldsberry et al.
Cancers, 12(3) (2020-03-28)
In ovarian cancer, upregulation of the Wnt/β-catenin pathway leads to chemoresistance and correlates with T cell exclusion from the tumor microenvironment (TME). Our objectives were to validate these findings in an independent cohort of ovarian cancer subjects and determine whether
David W Doo et al.
Therapeutic advances in medical oncology, 12, 1758835920913798-1758835920913798 (2020-04-22)
The Wnt/β-catenin pathway is linked to tumorigenesis in a variety of tumors and promotes T cell exclusion and resistance to checkpoint inhibitors. We sought to determine whether a small molecule inhibitor of this pathway, WNT974, would impair tumor growth, affect
查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持