推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
颜色
off-white to yellow
溶解性
water: 2.5 mg/mL
DMSO: 5 mg/mL
运输
ambient
储存温度
10-30°C
InChI
1S/C6H8ClN7O.ClH/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;/h(H4,8,9,13)(H4,10,11,14,15);1H
InChI key
ACHKKGDWZVCSNH-UHFFFAOYSA-N
一般描述
血管生成抑制剂。在低浓度下，可作为跨膜Na+进入和Na+/H+ATPase的有效和特异性抑制剂。抑制平滑肌对收缩刺激的反应。阻断水螅毒素诱导的电导的反应。降低跨管状上皮的电位。在较高浓度下，会阻断Na+/H+交换途径。
血管生成抑制剂。在约130 µM时完全可逆地抑制毛细血管形态发生。在低浓度下，可作为跨膜Na+进入和Na+，K+-ATPase的有效和特异性抑制剂。也可作为尿激酶型纤溶酶原激活物（uPA）的抑制剂。阻断平滑肌对骨骼肌中收缩刺激和水螅毒素诱导的电导的反应。降低跨管状上皮的电位。在较高浓度下，会阻断Na+/H+交换途径。
生化/生理作用
主要靶标
毛细血管形态发生
毛细血管形态发生
产物不与ATP竞争。
可逆性：是
细胞渗透性：否
靶标IC50：130 µM 完全可逆地抑制毛细血管形态发生
警告
毒性：有毒（F）
重悬
复溶后，等分并冷冻保存（-20°C）。储备水溶液在-20°C可稳定保存长达6个月。
其他说明
Knoll, A., et al. 1999.Microvasc.Res.58, 1.
Swiercz, R., et al. 1999.Oncol.Rep.6, 523.
Moran, A., et al. 1995.Am. J. Physiol.268, C350.
Alliegro, M.C., et al. 1993.J. Exp.Zool.267, 245.
Sugiyama, S., et al. 1988.J. Biol. Chem.263, 8215.
Yoshida, K., et al. 1988.Biochem.Biophys.Res. Commun.154, 101.
Sariban-Sotorabay, S., and Benos, D.J. 1986.Am. J. Physiol.250, C175.
Swiercz, R., et al. 1999.Oncol.Rep.6, 523.
Moran, A., et al. 1995.Am. J. Physiol.268, C350.
Alliegro, M.C., et al. 1993.J. Exp.Zool.267, 245.
Sugiyama, S., et al. 1988.J. Biol. Chem.263, 8215.
Yoshida, K., et al. 1988.Biochem.Biophys.Res. Commun.154, 101.
Sariban-Sotorabay, S., and Benos, D.J. 1986.Am. J. Physiol.250, C175.
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法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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