129874
Amifostine
A cell-permeable aminothiophosphate pro-drug that offers selective protection in many normal, but not in tumor, tissues against the toxic side-effects of radiation and cytotoxic drugs.
别名:
Amifostine, 2-(3-Aminopropyl)aminoethyl phosphorothioate, trihydrate, S-2-(3-Aminopropylamino)ethyl-O,O-dihydrogen phosphorothioate, trihydrate
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About This Item
推荐产品
质量水平
方案
≥99% (NMR)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated
protect from light
颜色
off-white
溶解性
water: soluble
运输
ambient
储存温度
2-8°C
InChI
1S/C5H15N2O3PS/c6-2-1-3-7-4-5-12-11(8,9)10/h7H,1-6H2,(H2,8,9,10)
InChI key
JKOQGQFVAUAYPM-UHFFFAOYSA-N
一般描述
A cell-permeable aminothiophosphate pro-drug that offers selective protection in many normal, but not in tumor, tissues against the toxic side-effects of radiation and cytotoxic drugs. Its cytoprotective activities have been attributed to its free radical scavenging properties of its active thiol metabolite, WR-1065. The critical step in its activation is its interaction with alkaline phosphatase that is differentially distributed in normal and neoplastic cells. A strong inducer of hypoxia-inducible factor-α1 (HIF-α1) and p53. Shown to reduce PARP proteolysis and levels of active caspase-3 in irradiated mouse ovaries.
包装
Packaged under inert gas
警告
Toxicity: Harmful (C)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Dedieu, S., et al. 2010. BMC Medicine8, 19.
Yoon, Y.D., et al. 2005. In Vivo19, 509.
Koukourakis, M.I., et al. 2004. Cancer Chemother. Pharmacol.53, 1.
Blasiak, J., et al. 2002. Leukemia Res.26, 1093.
Yoon, Y.D., et al. 2005. In Vivo19, 509.
Koukourakis, M.I., et al. 2004. Cancer Chemother. Pharmacol.53, 1.
Blasiak, J., et al. 2002. Leukemia Res.26, 1093.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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