126920
ALDH2 Agonist, Alda-1
The ALDH2 Agonist, Alda-1, also referenced under CAS 349438-38-6, controls the biological activity of ALDH2. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
别名:
ALDH2 Agonist, Alda-1, N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide
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About This Item
质量水平
检测方案
≥95% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
off-white
溶解性
ethanol: 10 mg/mL
DMSO: 100 mg/mL
运输
ambient
储存温度
2-8°C
InChI
1S/C15H11Cl2NO3/c16-10-2-1-3-11(17)14(10)15(19)18-7-9-4-5-12-13(6-9)21-8-20-12/h1-6H,7-8H2,(H,18,19)
InChI key
NMKJFZCBCIUYHI-UHFFFAOYSA-N
一般描述
A cell-permeable benzamide compound that selectively enhances the activity of both the wild-type ALDH2*1 and the east asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (2.1-, 2.2, and 11-fold activation of 20 µg wt homo, wt/mut hetero, and mut homo tetramer, respectively, at 100 µM), while exhibiting no effect toward alcohol dehydrogenase 1, cytosolic ALDH1, or mitochondrial ALDH5. Both PKCε activatior- and ethanol-mediated protections against heart tissue ischemic damage are reported to correlate well with ALDH2 activation, and Alda-1, likewise, is shown to protect against ischemic tissue damage to excised rat hearts (26% and 24% reduction in infarct size and CPK release, respectively; 20 µM) ex vivo and anesthetized live rats (60% infarction reduction; 8.5 mg/kg) in vivo.
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following, reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Chen, C.H., et al. 2008. Science321, 1493.
法律信息
Patent pending.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
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