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Merck
CN
所有图片(1)

文件

12-533

Sigma-Aldrich

GSM (GSK3 substrate peptide)

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UNSPSC代码:
12352200
eCl@ss:
32160405
NACRES:
NA.41

分子量

Mw 2673 Da

质量水平

制造商/商品名称

Upstate®

技术

activity assay: suitable (kinase)

NCBI登记号

UniProt登记号

运输

dry ice

应用

GSM (GSK3 substrate peptide) has been used:
  • in in vitro glycogen synthase kinase 3 (GSK-3)-3β activity assay to measure the kinase activity of GSK-3
  • as a supplement in perfusates in kinase activity assay to determine the effect of the phosphatase-activating domain (PAD) peptide on squid axoplasm
  • as a control in Kinase-Glo luminescent kinase assay to measure the influence of ibuprofen treatment on the catalytic activity of the kinase GSK3β

生化/生理作用

Glycogen synthase kinase 3 (GSK3) is a protein kinase, which regulates glycogen metabolism. It regulates various cell functions, like signaling by insulin, growth factors and nutrients, and the specification of cell fates during embryonic development. GSK3 is involved modulating in apoptosis, cell division, and microtubule function.

质量

Routinely evaluated as a substrate for GSK3β (Catalog # 14-306).

外形

1 mg of GSM lyophilized from 1 mL sterile, distilled water. Lyophilized powder.

储存及稳定性

Lyophilized: 2 years at -20°C. Rehydrated: 6 months at -20°C

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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