124032
Akt Inhibitor XIV
The Akt Inhibitor XIV, also referenced under CAS 1191951-57-1, controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Akt Inhibitor XIV, 4-Dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide, PDK1 Inhibitor III, PHT-427
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About This Item
推荐产品
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
white
溶解性
DMSO: 50 mg/mL
运输
ambient
储存温度
2-8°C
InChI
1S/C20H31N3O2S2/c1-2-3-4-5-6-7-8-9-10-11-12-18-13-15-19(16-14-18)27(24,25)23-20-22-21-17-26-20/h13-17H,2-12H2,1H3,(H,22,23)
InChI key
BYWWNRBKPCPJMG-UHFFFAOYSA-N
一般描述
A cell-permeable thiadiazolyl compound that binds to PH (pleckstrin homology) domain (Kd = 40.8 µM, Ki = 2.4 µM) and acts as a competitive and reversible blocker of Akt translocation to the cellular membrane with selectivity over PDK1 (Kd = 90.1 µM, Ki = 5.5 µM). Inhibits pAkt-Ser473 (IC50 = 6.3, 8.6 and 10 µM in Panc-1, BxPC-3 and MiaPaCa-2 cells, respectively), and induces apoptosis at 20 µM (40% and 31%) and causes growth arrest (IC50 = 65 and 30 µM) in Panc-1 and MiaPaCa-2 cells, respectively. Further, suppresses tumor growth and regression in mouse xenograft model (125 mg/kg, i.p.) and reduces pGSK-3α-Ser21 and pGSK-3β-Ser9 and p70S6K-Thr389 levels.
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Meuillet, E.J., et al. 2010. Mol. Cancer Ther. 9, 706.
Moses, S.A., et al. 2009. Cancer Res. 69, 5073.
Moses, S.A., et al. 2009. Cancer Res. 69, 5073.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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