124005
Akt抑制剂
The Akt Inhibitor controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Akt抑制剂, 1L6-羟甲基-手性肌醇-2-(R)-2-O-甲基-3-O-十八基-sn-碳酸甘油酯
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所有图片(1)
About This Item
经验公式（希尔记法）:
C30H58O10
分子量:
578.78
UNSPSC代码:
12352200
NACRES:
NA.77
推荐产品
质量水平
方案
≥98% (NMR)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
颜色
white to off-white
溶解性
DMSO: 200 mg/mL
运输
ambient
储存温度
−20°C
一般描述
一种具有细胞可渗透性、可逆性和底物竞争性的磷脂酰肌醇醚类似物，可有效和选择性地抑制Akt(PKB)（IC50为5.0 µM）。中度抑制PI 3-K活性（IC50 = 83.0 µM）。也抑制各种癌症细胞系的生长，IC50值在1-10 µM范围内。
生化/生理作用
产物与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：对于Akt (PKB)，5.0 µM
包装
用惰性气体包装
警告
毒性：标准处理（A）
重悬
使用无水DMSO进行复溶。
在复溶后，分装并冷冻保存（-20°C）。储备液可在-20°C最长稳定3周。
其他说明
Hu, Y., et al. 2000 J. Med. Chem.43, 3045.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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