123850
AKR1C1 Inhibitor, 5-PBSA
The AKR1C1 Inhibitor, 5-PBSA, also referenced under CAS 4906-68-7, controls the biological activity of AKR1C1.
别名:
AKR1C1 Inhibitor, 5-PBSA, Aldo-Keto Reductase family 1 member C1 Inhibitor, 5-PBSA, 3-Bromo-5-phenylsalicylic acid, 20α-Hydroxysteroid Dehydrogenase Inhibitor, 5-PBSA
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所有图片(2)
About This Item
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质量水平
方案
≥94% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 50 mg/mL
运输
wet ice
储存温度
2-8°C
SMILES字符串
OC1=C(C(O)=O)C=C(C2=CC=CC=C2)C=C1Br
InChI
1S/C13H9BrO3/c14-11-7-9(8-4-2-1-3-5-8)6-10(12(11)15)13(16)17/h1-7,15H,(H,16,17)
InChI key
XVZSXNULHSIRCQ-UHFFFAOYSA-N
一般描述
A cell-permeable salicylic acid compound that acts as a highly potent, active-site directed and substrate competitive AKR1C1 inhibitor (Ki = 4 nM) with moderate to excellent selectivity over AKR1C2, AKR1C3 and AKR1C4 (Ki = 0.087, 4.2 and 18.2 µM, respectively). Shown to inhibit the metabolism of progesterone by AKR1C1 (IC50 = 460 nM in AKR1C1 overexpressing BAECs).
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
El-Kabbani, O., et al. 2011. J. Steroid Biochem. Mol. Biol.125, 105.
El-Kabbani, O., et al. 2009. J. Med. Chem.52, 3259.
El-Kabbani, O., et al. 2009. J. Med. Chem.52, 3259.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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