推荐产品
质量水平
方案
≥98% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
white to brown
溶解性
methanol: 10 mg/mL
water: soluble
运输
ambient
储存温度
2-8°C
SMILES字符串
[n]2(cnc(c2N)C(=O)N)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO
InChI
1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1
InChI key
RTRQQBHATOEIAF-UUOKFMHZSA-N
一般描述
一种在细胞内加工形成磷酸化代谢物的细胞渗透性嘧啶核苷化合物，该代谢物可激活腺苷一磷酸激活的蛋白激酶（AMPK），而不会破坏ATP、ADP或AMP的细胞浓度。还充当从头嘌呤合成的调节剂。刺激灌注和离体肌肉中的葡萄糖摄取。AICAr刺激的葡萄糖转运不受PI-3K抑制剂渥曼青霉素（目录编号681675）的影响。已显示可抑制三酰基甘油（TAG），二酰基甘油（DAG）和磷脂的合成，这可能是AMPK激活以及随后AMPK抑制sn-甘油-3-磷酸酰基转移酶（GPAT）的结果。还报道抑制Hsp90伴侣功能。提供针对葡萄糖剥夺、化学缺氧以及暴露于谷氨酸和淀粉样蛋白β（Aβ）肽引起的细胞死亡的保护。
一种细胞可渗透的嘧啶核苷化合物，其磷酸化代谢物激活单磷酸腺苷活化蛋白激酶（AMPK）并作为从头嘌呤合成的调节剂。刺激灌注和离体肌肉中的葡萄糖摄取。提供针对葡萄糖剥夺、化学缺氧以及暴露于谷氨酸和Aβ肽引起的细胞死亡的保护。
生化/生理作用
主要靶标
腺苷单磷酸激活蛋白激酶（AMPK）
腺苷单磷酸激活蛋白激酶（AMPK）
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
包装
用惰性气体包装
警告
毒性：标准处理（A）
制备说明
可能需要加热到50°C才能完全溶解在甲醇中。
重悬
在复溶后，分装并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
其他说明
Meli, M., et al. 2006.J. Med. Chem.in press.
Culmsee, C., et al. 2001.J. Mol.Neurosci.17, 45.
Muoio, D.M., et al. 1999.Biochem.J.338, 783.
Hayashi, T., et al. 1998.Diabetes47, 1369.
Corton, J.M., et al. 1995.Eur. J. Biochem.229, 558.
Culmsee, C., et al. 2001.J. Mol.Neurosci.17, 45.
Muoio, D.M., et al. 1999.Biochem.J.338, 783.
Hayashi, T., et al. 1998.Diabetes47, 1369.
Corton, J.M., et al. 1995.Eur. J. Biochem.229, 558.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
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