产品名称
阿卡地新, AICA-Riboside, CAS 2627-69-2, is a cell-permeable nucleoside compound whose phosphorylated metabolite activates AMPK and acts as a regulator of de novo purine synthesis.
SMILES string
[n]2(cnc(c2N)C(=O)N)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO
InChI
1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1
InChI key
RTRQQBHATOEIAF-UUOKFMHZSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white to brown
solubility
methanol: 10 mg/mL
water: soluble
shipped in
ambient
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
主要靶标
腺苷单磷酸激活蛋白激酶（AMPK）
腺苷单磷酸激活蛋白激酶（AMPK）
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
Disclaimer
毒性：标准处理（A）
General description
一种在细胞内加工形成磷酸化代谢物的细胞渗透性嘧啶核苷化合物，该代谢物可激活腺苷一磷酸激活的蛋白激酶（AMPK），而不会破坏ATP、ADP或AMP的细胞浓度。还充当从头嘌呤合成的调节剂。刺激灌注和离体肌肉中的葡萄糖摄取。AICAr刺激的葡萄糖转运不受PI-3K抑制剂渥曼青霉素（目录编号681675）的影响。已显示可抑制三酰基甘油（TAG），二酰基甘油（DAG）和磷脂的合成，这可能是AMPK激活以及随后AMPK抑制sn-甘油-3-磷酸酰基转移酶（GPAT）的结果。还报道抑制Hsp90伴侣功能。提供针对葡萄糖剥夺、化学缺氧以及暴露于谷氨酸和淀粉样蛋白β（Aβ）肽引起的细胞死亡的保护。
一种细胞可渗透的嘧啶核苷化合物，其磷酸化代谢物激活单磷酸腺苷活化蛋白激酶（AMPK）并作为从头嘌呤合成的调节剂。刺激灌注和离体肌肉中的葡萄糖摄取。提供针对葡萄糖剥夺、化学缺氧以及暴露于谷氨酸和Aβ肽引起的细胞死亡的保护。
Other Notes
Meli, M., et al. 2006.J. Med. Chem.in press.
Culmsee, C., et al. 2001.J. Mol.Neurosci.17, 45.
Muoio, D.M., et al. 1999.Biochem.J.338, 783.
Hayashi, T., et al. 1998.Diabetes47, 1369.
Corton, J.M., et al. 1995.Eur. J. Biochem.229, 558.
Culmsee, C., et al. 2001.J. Mol.Neurosci.17, 45.
Muoio, D.M., et al. 1999.Biochem.J.338, 783.
Hayashi, T., et al. 1998.Diabetes47, 1369.
Corton, J.M., et al. 1995.Eur. J. Biochem.229, 558.
Packaging
用惰性气体包装
Preparation Note
可能需要加热到50°C才能完全溶解在甲醇中。
在复溶后，分装并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
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