ligand
(Sulfoisobutyl)
sterility
sterile (Caustic Stable)
product line
Eshmuno®
form
resin
specific analyte(s)
MAbs
parameter
1000 cm/hr flow rate
8 bar max. pressure
matrix active group
polymer, Polyvinyl Ether
mean particle size
85 μm
capacity
165 mg binding capacity (lysozyme/ml of resin)
transition temp
flash point 35 °C (own results)
application(s)
recombinant protein
vaccine development
separation technique
cation exchange
storage temp.
2-30°C
Analysis Note
Appearance: Milky cream coloured turbid suspension, free from coarse mechanical impurities.
Microscopic evaluation: Spherical particles, no agglomerates, no fines.
Extractable matter (water): ≤ 0.08 %
Ionic capacity: 50 - 100 µeq/ml
Performance test (chymotrypsinogen): 10 - 30 mS/cm
Performance test (lysozyme): 35 - 55 mS/cm
Pressure drop(column: ID=1.6 cm, L=10 cm at 5 ml/min): ≤ 1.0 bar
Protein binding capacity (lysozyme): 120 - 180 mg/ml
Particle size (50-120 µm): ≥ 80 %
Particle size (d50): 75 - 95 µm
Cerium: ≤ 30 µg/g
Endotoxins: ≤ 1.00 EU/ml
TAMC (total aerobic microbial count): ≤ 100 CFU/ml
TYMC (total yeast and mould count): ≤ 100 CFU/ml
Microscopic evaluation: Spherical particles, no agglomerates, no fines.
Extractable matter (water): ≤ 0.08 %
Ionic capacity: 50 - 100 µeq/ml
Performance test (chymotrypsinogen): 10 - 30 mS/cm
Performance test (lysozyme): 35 - 55 mS/cm
Pressure drop(column: ID=1.6 cm, L=10 cm at 5 ml/min): ≤ 1.0 bar
Protein binding capacity (lysozyme): 120 - 180 mg/ml
Particle size (50-120 µm): ≥ 80 %
Particle size (d50): 75 - 95 µm
Cerium: ≤ 30 µg/g
Endotoxins: ≤ 1.00 EU/ml
TAMC (total aerobic microbial count): ≤ 100 CFU/ml
TYMC (total yeast and mould count): ≤ 100 CFU/ml
Features and Benefits
Eshmuno® S chromatography resin enables:
- Purification of basic and neutral proteins (e.g., antibodies) and peptides specifically designed for highly productive downstream bioprocessing
- High flow rate applications
- High separation efficiency over a broad range of flow rates with a rigid matrix and optimized pore structure
- Tentacle technology which provides high yield, selectivity, and focused elution
- Multiple CIP and packing cycles with the chemically and physically robust bead, leading to a longer resin lifetime
- Compatibility with 1 % (v/v) aqueous benzyl alcohol containing 150 mM NaCl and storage solutions 0.1 M NaOH
General description
The first member of the Eshmuno® resin family, designed specifically for highly productive downstream bioprocessing
Packaging
- 1.20078.0100: Eshmuno® S Resin 100ml
- 1.20078.0010: Eshmuno® S Resin 10ml
- 1.20078.0500: Eshmuno® S Resin 500ml
- 1.20078.5000: Eshmuno® S Resin 5L
Plastic bottle
Legal Information
Eshmuno is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Flam. Liq. 3
存储类别
3 - Flammable liquids
wgk
WGK 1
flash_point_f
95.0 °F
flash_point_c
35 °C
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