119137
CGS 21680 hydrochloride
≥96% (HPLC), solid, adenosine A2A receptor agonist, Calbiochem®
别名:
腺苷A2A受体激动剂I，CGS 21680，盐酸盐, CGS-21680，CGS21680，3-（4-（2-（（6-氨基-9-（（2R,3R,4S,5S）-5-（乙基氨甲酰基）-3,4-二羟基四氢呋喃-2-基）-9H-嘌呤-2-基）氨基）乙基）苯基）丙酸
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所有图片(1)
About This Item
经验公式（希尔记法）:
C23H29N7O6 · xHCl
CAS号:
分子量:
499.52 (free base basis)
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
推荐产品
产品名称
腺苷A2A受体激动剂I，CGS 21680，盐酸盐,
方案
≥96% (HPLC)
质量水平
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 100 mM
运输
ambient
储存温度
−20°C
SMILES字符串
[n]2(c3nc(nc(c3nc2)N)NCCc4ccc(cc4)CCC(=O)O)C1O[C@@H]([C@H]([C@H]1O)O)C(=O)NCC
InChI
1S/C23H29N7O6/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29)/t16-,17+,18-,22?/m0/s1
InChI key
PAOANWZGLPPROA-OFRRTHGGSA-N
一般描述
CGS 21680 is a potent adenosine A2A receptors agonist (Ki = 27 nM) and xanthin derivative. CGS 21680 HCl exhibits reduced affinity for A2B receptors (Ki = 67 nM), but offers greater selectivity over A1R (Ki = 290 nM) and A3R (88.8 µM). Exerts an anti-inflammatory effect during chronic inflammation and ameliorates the tissue damage associated with collagen-induced arthritis. Been, shown to reduce CCR7 Protein Expression in THP1 macrophages. Shown to delay the progressive deterioration of motor performance and prevent a reduction in brain weight in murine model of Huntington′s disease.
包装
用惰性气体包装
警告
毒性：标准处理（A）
外形
以盐酸盐形式提供。
重悬
在复溶后，分装并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
其他说明
The molecular weight of CGS 21680 Hydrochloride this compound is batch-specific due to variable water content. For batch-specific molecular weight information, please refer the vial label or the certificate of analysis. The provided molecular weight represents the baseline molecular weight without water.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Cinthia Rangel-Sandoval et al.
iScience, 27(5), 109681-109681 (2024-04-29)
Pannexins are large-pore ion channels expressed throughout the mammalian brain that participate in various neuropathologies; however, their physiological roles remain obscure. Here, we report that pannexin1 channels (Panx1) can be synaptically activated under physiological recording conditions in rodent acute hippocampal
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