Adenylyl Cyclase Type V Inhibitor, NKY80

A cell-permeable quinazolinone containing a non-nucleoside compound that acts as a potent, selective inhibitor of adenylyl cyclase (AC) type V isoform (IC₅₀ = 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively) in the presence of G_sα GTPγS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Regulates the AC catalytic activity in heart and lung tissues.

A cell-permeable, non-nucleoside compound that acts as a potent, and selective inhibitor of adenylyl cyclase (AC) type V (IC₅₀ = 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively) in the presence of G₅α GTPγS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Reported to regulate AC catalytic activity in heart and lung tissues.

Cell permeable: yes

Primary Target
Adenylate cyclase (AC) type V isoform

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 8.3 µM, 132 µM and 1.7 mM for type V, III and II, of adenylyl cyclase (AC), respectively, in the presence of Gsα GTPγS-Forskolin

Packaged under inert gas

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Onda, T., et al. 2001. J. Biol. Chem.276, 47785.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany