跳转至内容
Merck
CN
所有图片(2)

文件

112252

Sigma-Aldrich

Acidic Mammalian Chitinase Inhibitor, Bisdionin F

The Acidic Mammalian Chitinase Inhibitor, Bisdionin F controls the biological activity of Acidic Mammalian Chitinase.

别名:

Acidic Mammalian Chitinase Inhibitor, Bisdionin F, AMCase Inhibitor, 3,7-dimethyl-1-(3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)propyl)-1H-purine-2,6(3H,7H)-dione

登录查看公司和协议定价


About This Item

经验公式(希尔记法):
C16H18N8O4
分子量:
386.37
UNSPSC代码:
12352106
NACRES:
NA.54

质量水平

检测方案

≥95% (HPLC)

形式

powder

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

off-white

溶解性

DMSO: 5 mg/mL, clear, nearly colorless

运输

ambient

储存温度

2-8°C

SMILES字符串

CN(C=N1)C2=C1N(C)C(N(C2=O)CCCN3C(N(C)C(N=CN4)=C4C3=O)=O)=O

一般描述

A cell-permeable, competitive Acidic Mammalian Chitinase (AMCase) Inhibitor (IC50 = 0.92 µM and Ki = 0.42 µM for hAMCase, and IC50= 2.2 µM for mAMCase, in vitro) that demonstrates 20-fold selectivity for hAMCase over hCHIT1. It is shown to decrease chitinase enzymatic activity (5 mg/kg, i.p.) in the lungs of control PBS- and OVA-challenged mice. Furthermore, it attenuates lung chitinase activity, reduces eosinophil influx, and improves ventilatory function, in vivo, in a murine model of allergic inflammation. It also causes neutrophilia in the lungs of OVA-challenged mice.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

其他说明

Sutherland, T.E., et al. 2011. Chem. Biol.18, 569.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Yifan Wu et al.
PLoS neglected tropical diseases, 18(2), e0011930-e0011930 (2024-02-07)
Ascariasis (roundworm) is the most common parasitic helminth infection globally and can lead to significant morbidity in children including chronic lung disease. Children become infected with Ascaris spp. via oral ingestion of eggs. It has long been assumed that Ascaris

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门