Agency
BP
JP
Ph. Eur.
USP
质量水平
管理合规性
FCC
产品线
EMPROVE® ESSENTIAL
形式
solid
效能
6450 mg/kg LD50, oral (Rat)
>2000 mg/kg LD50, skin (Rat)
pH值（酸碱度）
9.5-10.5 (20 °C, 100 g/L in H2O, slurry)
mp
825 °C (decomposition)
密度
2.93 g/mL at 25 °C (lit.)
应用
liquid formulation
pharmaceutical
solid formulation
储存温度
2-30°C
SMILES字符串
[Ca++].[O-]C([O-])=O
InChI
1S/CH2O3.Ca/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2
InChI key
VTYYLEPIZMXCLO-UHFFFAOYSA-L
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一般描述
Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.
应用
Calcium carbonate is typically used as alkalizer or mineral supplement in solid formulations. The low aluminum content is relevant for baby food application.
法律信息
Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
13 - Non Combustible Solids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
J P Hilton-Proctor et al.
European journal of medicinal chemistry, 191, 112120-112120 (2020-03-03)
N-Methylpyrrolidone is one of several chemotypes that have been described as a mimetic of acetyl-lysine in the development of bromodomain inhibitors. In this paper, we describe the synthesis of a 4-phenyl substituted analogue - 1-methyl-4-phenylpyrrolidin-2-one - and the use of
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