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product name
LiChrosorb® RP-18 (5 µm),
物料
stainless steel column
Agency
suitable for USP L1
产品线
LiChrosorb®
特点
endcapped: no
参数
60 °C max. temp.
技术
HPLC: suitable
mass spectrometry (MS): suitable (Low)
基质
fully porous particle
基质活性基团
C18 bonding phase
粒径
10 μm
孔径
100 Å pore size
operating pH range
2-7.5
堆积密度
200‑400 kg/m3
分离技术
reversed phase
储存温度
no temp limit
相关类别
一般描述
LiChrosorb® RP-18 is a reliable irregular shaped silica gel carriers with reversed phase properties. It is well suited for the separation of neutral, acidic and weak basic compounds.
应用
- Determination of berberine in human serum by reversed-phase high performance liquid chromatography.: This study outlines a method for detecting berberine in human serum using reversed-phase HPLC, utilizing the LiChrosorb RP-18 column for its reliability in separating chemical compounds in biological samples (Sun Y et al., 1997).
- Kinetics of hydrolysis of 4-methoxy-2-[2-hydroxy-3(4-phenyl-1-piperazinyl)]propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c]pyridine in aqueous solutions.: This research employs RP-18 to study the stability and hydrolysis kinetics of a complex organic compound, highlighting its application in pharmaceutical analysis (Muszalska I et al., 2004).
- A validated spectrophotometric and liquid chromatography method for determination and purity evaluation of 4-methoxy-2-[2-hydroxy-3(4-phenyl-1-piperazinyl)]propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c]pyridine.: This paper details the use of RP-18 in validating a method for assessing the purity of pharmaceutical compounds, demonstrating its essential role in quality control (Muszalska I et al., 2003).
- High-performance liquid chromatographic determination of the antifungal drug fluconazole in plasma and saliva of human immunodeficiency virus-infected patients.: This study utilizes RP-18 to monitor fluconazole in clinical samples, providing insights into the pharmacokinetics and therapeutic monitoring of antifungal treatment in HIV patients (Beijnen JH et al., 1995).
- Ion-pair solid-phase extraction of cimetidine from plasma and subsequent analysis by high-performance liquid chromatography.: Describes a method using RP-18 for the extraction and analysis of cimetidine, a drug used to treat heartburn and peptic ulcers, from plasma samples, illustrating its versatility in drug analysis (Russel FG et al., 1994).
分析说明
Theoretical Plates (N/m) (Toluene): ≥ 60000
stability testing (performance): passes test
separation factor (Acetophenone/Phenol, selectivity test): 1.8 - 2.2
separation factor (Acetophenone/Cinnamic acid, selectivity test): 1.1 - 1.4
separation factor (1-Naphtol/Phenol, selectivity test): 3.9 - 4.7
capacity factor (Toluene): 16.0 - 21.0
Particle Size (d10): 3.8 - 4.3 µm
Particle Size (d50): 6.7 - 7.7 µm
Particle Size (d90): 12.0 - 14.0 µm
stability testing (performance): passes test
separation factor (Acetophenone/Phenol, selectivity test): 1.8 - 2.2
separation factor (Acetophenone/Cinnamic acid, selectivity test): 1.1 - 1.4
separation factor (1-Naphtol/Phenol, selectivity test): 3.9 - 4.7
capacity factor (Toluene): 16.0 - 21.0
Particle Size (d10): 3.8 - 4.3 µm
Particle Size (d50): 6.7 - 7.7 µm
Particle Size (d90): 12.0 - 14.0 µm
法律信息
LiChrosorb is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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