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Merck
CN

1.06757

4-羟基苯甲酸甲酯

EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, NF

别名:

Methyl 4-hydroxybenzoate, Methylparaben, 4-Hydroxybenzoic acid methyl ester

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关于此项目

线性分子式:
4-(OH)C6H4(COOCH3)
化学文摘社编号:
99-76-3
分子量:
152.15
UNSPSC Code:
12352108
EC Index Number:
202-785-7
MDL number:
MFCD00002352

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产品名称

4-羟基苯甲酸甲酯, EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, NF

agency

NF
BP
ChP
JP
Ph. Eur.

SMILES string

O(C)C(=O)c1ccc(cc1)O

InChI

1S/C8H8O3/c1-11-8(10)6-2-4-7(9)5-3-6/h2-5,9H,1H3

InChI key

LXCFILQKKLGQFO-UHFFFAOYSA-N

vapor pressure

0.000005 hPa ( 20 °C)

product line

EMPROVE® EXPERT

assay

99.0-100.5% (HPLC)
99.0-102.0% (acidimetric)

form

solid

autoignition temp.

>600 °C

technique(s)

API processing | cocrystal formation: suitable

pH

5.8 (20 °C in H2O, saturated solution)

mp

125 °C

solubility

1.88 g/L

density

1.38 g/cm3 at 20 °C

application(s)

liquid formulation
ophthalmics
parenterals
pharmaceutical
semi-solid formulation
solid formulation

storage temp.

15-25°C

Quality Level

500

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相关类别

Application

Methyl 4-hydroxybenzoate has antimicrobial characteristics and is used as preservative in pharmaceutical formulations and cosmetics. It can be combined with other parabens like propyl 4-hydroxybenzoate or ethyl 4-hydroxybenzoate.

Disclaimer

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Environment
GHS09

hcodes

H411

Hazard Classifications

Aquatic Chronic 2

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

334.4 °F

flash_point_c

168 °C

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