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Merck
CN

1.06756

4-羟基苯甲酸甲酯钠盐

EMPROVE® ESSENTIAL, Ph. Eur., BP, NF

别名:

Methyl 4-hydroxybenzoate sodium salt, 4-Hydroxybenzoic acid methyl ester sodium salt, Methylparaben sodium salt

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关于此项目

线性分子式:
Na+[4-(O)C6H4(COOCH3)]-
化学文摘社编号:
5026-62-0
分子量:
174.13
UNSPSC Code:
12352108
EC Index Number:
225-714-1
MDL number:
MFCD00016470

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产品名称

4-羟基苯甲酸甲酯钠盐, EMPROVE® ESSENTIAL, Ph. Eur., BP, NF

SMILES string

[Na+].[O-]c1ccc(cc1)C(=O)OC

InChI

1S/C8H8O3.Na/c1-11-8(10)6-2-4-7(9)5-3-6;/h2-5,9H,1H3;/q;+1/p-1

InChI key

PESXGULMKCKJCC-UHFFFAOYSA-M

agency

BP
NF
Ph. Eur.

product line

EMPROVE® ESSENTIAL

form

solid

autoignition temp.

>600 °C

pH

9.7-10.3 (1 g/L in H2O)

mp

>125 °C

density

1.42 g/cm3 at 20 °C

application(s)

liquid formulation
ophthalmics
pharmaceutical
semi-solid formulation
solid formulation

storage temp.

15-25°C

Quality Level

500

相关类别

Application

Methyl 4-hydroxybenzoate has antimicrobial characteristics and is used as preservative in pharmaceutical formulations and cosmetics. It can be combined with other parabens like propyl 4-hydroxybenzoate or ethyl 4-hydroxybenzoate. The sodium salt provides improved solubility in water compared to standard methyl 4-hydroxybenzoate.

Disclaimer

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Corrosion
GHS05

signalword

Danger

Hazard Classifications

Aquatic Chronic 3 - Eye Dam. 1 - Skin Irrit. 2

存储类别

11 - Combustible Solids

wgk

WGK 1

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Ambra Masuzzo et al.
eLife, 8 (2019-10-30)
When facing microbes, animals engage in behaviors that lower the impact of the infection. We previously demonstrated that internal sensing of bacterial peptidoglycan reduces Drosophila female oviposition via NF-κB pathway activation in some neurons (Kurz et al., 2017). Although we

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