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Merck
CN

1.00662

山梨酸

EMPROVE® ESSENTIAL, Ph. Eur., BP, ChP, NF, FCC, E 200

别名:

Sorbic acid, 2,4-Hexadienic acid

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关于此项目

经验公式（希尔记法）:
C6H8O2
化学文摘社编号:
110-44-1
分子量:
112.13
UNSPSC Code:
12352106
E Number:
E200
EC Index Number:
203-768-7
MDL number:
MFCD00002703

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产品名称

山梨酸, EMPROVE® ESSENTIAL, Ph. Eur., BP, ChP, NF, FCC, E 200

SMILES string

OC(=O)\C=C\C=C\C

InChI

1S/C6H8O2/c1-2-3-4-5-6(7)8/h2-5H,1H3,(H,7,8)/b3-2+,5-4+

InChI key

WSWCOQWTEOXDQX-MQQKCMAXSA-N

agency

BP
ChP
NF
Ph. Eur.

reg. compliance

FCC

vapor pressure

0.00018 hPa ( 20 °C)

product line

EMPROVE® ESSENTIAL

assay

99.0-101.0% substance (anhydrous) basis (acidimetric)

form

solid

autoignition temp.

>130 °C

technique(s)

API processing | cocrystal formation: suitable
API processing | salt formation: suitable

pH

3.3 (20 °C, 1.6 g/L in H2O)

bp

160-260 °C/1013 hPa (decomposition)

mp

120-150 °C

solubility

1.6 g/L

density

1.2 g/cm3 at 20 °C

cation traces

As: ≤0.0003%
Cd: ≤0.001%
Cu: ≤0.001%
Hg: ≤0.0001%
Pb: ≤0.0002%
Zn: ≤0.001%
heavy metals (as Pb): ≤0.0010%

application(s)

liquid formulation
ophthalmics
pharmaceutical
semi-solid formulation
solid formulation

storage temp.

15-25°C

Quality Level

500

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相关类别

Application

Sorbic acid is commonly used as a preservative in pharmaceutical formulations and cosmetics. It is also used as additive for the preservation of food.

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our EMPROVE® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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Criteria for Selecting Preservatives Used in Liquid Formulation

Find key considerations for the selection and use of preservatives in a range of different therapeutic applications including topical, oral, transmucosal, inhalation, and otic, as well as injectables.

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