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Merck
CN

1.00162

硼酸

powder, EMPROVE® ESSENTIAL, Ph. Eur., BP, JP, NF, ChP

别名:

Orthoboric acid, Trihydroxidoboron

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线性分子式:
H3BO3
化学文摘社编号:
10043-35-3
分子量:
61.83
UNSPSC Code:
12352301
EC Index Number:
233-139-2
MDL number:
MFCD00011337

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产品名称

硼酸, powder, EMPROVE® ESSENTIAL, Ph. Eur., BP, JP, NF, ChP

InChI

1S/BH3O3/c2-1(3)4/h2-4H

SMILES string

OB(O)O

InChI key

KGBXLFKZBHKPEV-UHFFFAOYSA-N

agency

BP
ChP
JP
NF
Ph. Eur.

Quality Level

500

vapor pressure

2.6 mmHg ( 20 °C)

product line

EMPROVE® ESSENTIAL

assay

99.5-100.5% dry basis (alkalimetric)

form

powder
solid

pH

3.8-4.8 (20 °C, 33 g/L in H2O)

mp

160 °C (dec.) (lit.)

solubility

49.2 g/L

density

1.489 g/cm3 at 23 °C

anion traces

sulfate (SO42-): ≤0.04%

cation traces

As: ≤0.0001%
heavy metals (as Pb): ≤0.0015%

application(s)

liquid formulation
ophthalmics
pharmaceutical
semi-solid formulation

storage temp.

2-30°C

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相关类别

Application

Boric acid has antimicrobial characteristics and is therefore typically used as preservative in pharmaceutical formulations and cosmetics. It is also used as buffering agent and pH adjuster.

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Preparation Note

Must be subjected to further processing during the preparation of injectable dosage forms.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360FD

Hazard Classifications

Repr. 1B

存储类别

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Criteria for Selecting Preservatives Used in Liquid Formulation

Find key considerations for the selection and use of preservatives in a range of different therapeutic applications including topical, oral, transmucosal, inhalation, and otic, as well as injectables.

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